{"title":"老年人群饮食中活微生物摄入量与全因死亡率和心血管死亡率的关系:来自NHANES 2003-2018的证据","authors":"Shuang Zheng , Yanqing Lou , Jiali Zhang , Yu Wang , Lugang Lv","doi":"10.1016/j.archger.2024.105741","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>The relationship between dietary live microbe intake, non-dietary prebiotics/probiotics, and mortality in older adults remains unclear.</div></div><div><h3>Methods</h3><div>Participants from the National Health and Nutrition Examination Survey 2003–2018 were included. Participants were categorized into three groups based on estimated live microbe intake: low, medium, and high. Additionally, they were divided by their consumption of foods with medium or high microbial content. Text mining was employed to identify the use of non-dietary prebiotics and probiotics by analyzing the names and ingredients of dietary supplements and drugs. Associations between live microbe intake, non-dietary prebiotics/probiotics, and all-cause or cardiovascular mortality were assessed using Kaplan-Meier survival curves and Cox regression models. Inverse Probability of Treatment Weighting was used for sensitivity analysis</div></div><div><h3>Result</h3><div>A total of 7882 participants were included in the study. During a mean follow-up of 8.08 years, all-cause mortality was 18 % lower in older adults with high dietary live microbe intake in fully adjusted models (HR, 0.82; 95 %CI 0.70–0.96), and cardiovascular mortality was reduced by 23 % (HR, 0.77; 95 %CI 0.61–0.98). The risk of all-cause mortality was reduced by 21 % in the G3 group compared with the G1 group (HR, 0.79; 95 % CI 0.69–0.89) and a 29 % reduction in the risk of cardiovascular disease-specific death (HR, 0.71;95 %CI 0.59–0.86). In addition, we also observed that nondietary prebiotic and probiotic supplement intake was also associated with a reduced risk of mortality in an older US population.</div></div><div><h3>Conclusion</h3><div>In older U.S. adults, higher dietary live microorganisms and non-dietary probiotics/prebiotics intake was associated with a reduced risk of all-cause and cardiovascular mortality.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105741"},"PeriodicalIF":3.5000,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of dietary live microbe intake with all-cause and cardiovascular mortality in an older population: Evidence from NHANES 2003-2018\",\"authors\":\"Shuang Zheng , Yanqing Lou , Jiali Zhang , Yu Wang , Lugang Lv\",\"doi\":\"10.1016/j.archger.2024.105741\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>The relationship between dietary live microbe intake, non-dietary prebiotics/probiotics, and mortality in older adults remains unclear.</div></div><div><h3>Methods</h3><div>Participants from the National Health and Nutrition Examination Survey 2003–2018 were included. Participants were categorized into three groups based on estimated live microbe intake: low, medium, and high. Additionally, they were divided by their consumption of foods with medium or high microbial content. Text mining was employed to identify the use of non-dietary prebiotics and probiotics by analyzing the names and ingredients of dietary supplements and drugs. Associations between live microbe intake, non-dietary prebiotics/probiotics, and all-cause or cardiovascular mortality were assessed using Kaplan-Meier survival curves and Cox regression models. Inverse Probability of Treatment Weighting was used for sensitivity analysis</div></div><div><h3>Result</h3><div>A total of 7882 participants were included in the study. During a mean follow-up of 8.08 years, all-cause mortality was 18 % lower in older adults with high dietary live microbe intake in fully adjusted models (HR, 0.82; 95 %CI 0.70–0.96), and cardiovascular mortality was reduced by 23 % (HR, 0.77; 95 %CI 0.61–0.98). The risk of all-cause mortality was reduced by 21 % in the G3 group compared with the G1 group (HR, 0.79; 95 % CI 0.69–0.89) and a 29 % reduction in the risk of cardiovascular disease-specific death (HR, 0.71;95 %CI 0.59–0.86). 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引用次数: 0
摘要
背景:老年人膳食中活微生物摄入量、非膳食益生元/益生菌与死亡率之间的关系尚不清楚。方法:纳入2003-2018年全国健康与营养检查调查的参与者。参与者根据估计的活微生物摄入量被分为三组:低、中、高。此外,他们还根据食用微生物含量中等或较高的食物进行了分类。通过分析膳食补充剂和药物的名称和成分,采用文本挖掘方法识别非膳食益生元和益生菌的使用情况。使用Kaplan-Meier生存曲线和Cox回归模型评估活微生物摄入量、非膳食益生元/益生菌与全因或心血管死亡率之间的关系。采用处理加权逆概率法进行敏感性分析结果:共纳入7882名受试者。在平均8.08年的随访期间,在完全调整模型中,饮食中活微生物摄入量高的老年人的全因死亡率降低了18% (HR, 0.82;95% CI 0.70-0.96),心血管死亡率降低23% (HR, 0.77;95% ci 0.61-0.98)。与G1组相比,G3组全因死亡风险降低21% (HR, 0.79;95% CI 0.69-0.89),心血管疾病特异性死亡风险降低29% (HR 0.71; 95% CI 0.59-0.86)。此外,我们还观察到,非膳食益生元和益生菌补充剂的摄入也与美国老年人死亡率的降低有关。结论:在美国老年人中,较高的饮食活微生物和非饮食益生菌/益生元摄入量与全因死亡率和心血管死亡率的降低有关。
Association of dietary live microbe intake with all-cause and cardiovascular mortality in an older population: Evidence from NHANES 2003-2018
Background
The relationship between dietary live microbe intake, non-dietary prebiotics/probiotics, and mortality in older adults remains unclear.
Methods
Participants from the National Health and Nutrition Examination Survey 2003–2018 were included. Participants were categorized into three groups based on estimated live microbe intake: low, medium, and high. Additionally, they were divided by their consumption of foods with medium or high microbial content. Text mining was employed to identify the use of non-dietary prebiotics and probiotics by analyzing the names and ingredients of dietary supplements and drugs. Associations between live microbe intake, non-dietary prebiotics/probiotics, and all-cause or cardiovascular mortality were assessed using Kaplan-Meier survival curves and Cox regression models. Inverse Probability of Treatment Weighting was used for sensitivity analysis
Result
A total of 7882 participants were included in the study. During a mean follow-up of 8.08 years, all-cause mortality was 18 % lower in older adults with high dietary live microbe intake in fully adjusted models (HR, 0.82; 95 %CI 0.70–0.96), and cardiovascular mortality was reduced by 23 % (HR, 0.77; 95 %CI 0.61–0.98). The risk of all-cause mortality was reduced by 21 % in the G3 group compared with the G1 group (HR, 0.79; 95 % CI 0.69–0.89) and a 29 % reduction in the risk of cardiovascular disease-specific death (HR, 0.71;95 %CI 0.59–0.86). In addition, we also observed that nondietary prebiotic and probiotic supplement intake was also associated with a reduced risk of mortality in an older US population.
Conclusion
In older U.S. adults, higher dietary live microorganisms and non-dietary probiotics/prebiotics intake was associated with a reduced risk of all-cause and cardiovascular mortality.
期刊介绍:
Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published.
Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.