罕见并发肺部感染：抗mda5抗体阳性皮肌炎患者的烟曲霉和增生性绵孢菌。

IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Mycology Case Reports Pub Date : 2024-12-05 DOI:10.1016/j.mmcr.2024.100689

Maaya Fukumura , Ryosuke Hiwa , Satomi Yukawa , Yasuhiro Tsuchido , Hajime Yoshifuji , Akio Morinobu

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引用次数: 0

摘要

患者为59岁女性，抗mda5抗体阳性皮肌炎患者，应用强的松龙、他克莫司、环磷酰胺、托法替尼和血浆置换治疗。治疗5个月后，患者β- d -葡聚糖水平升高，CT上可见肺影。鉴定出烟曲霉，导致伏立康唑起始。后来发现新的肺部病变，发现有增生性扁孢子菌。考虑到伏立康唑耐药，加用特比萘芬，临床改善。警惕感染监测是至关重要的抗mda5抗体阳性皮肌炎治疗。

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Uncommon concurrent pulmonary infections: Aspergillus fumigatus and Lomentospora prolificans in an Anti-MDA5 antibody-positive dermatomyositis patient

A 59-year-old female with anti-MDA5 antibody-positive dermatomyositis was treated with prednisolone, tacrolimus, cyclophosphamide, tofacitinib, and plasma exchange. Five months post-treatment, elevated β-D-glucan levels and a pulmonary shadow on CT were noted. Aspergillus fumigatus was identified, leading to voriconazole initiation. A new pulmonary cavity lesion later revealed Lomentospora prolificans. Considering voriconazole resistance, terbinafine was added, resulting in clinical improvement. Vigilant infection monitoring is crucial during anti-MDA5 antibody-positive dermatomyositis treatment.

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来源期刊

Medical Mycology Case Reports MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

47 days