Raymond J So, Kimberley S Noij, Jiangxia Wang, Jonathan Walsh, Christine G Gourin, Carolyn M Jenks
{"title":"1998 - 2019年先天性巨细胞病毒感染的国家和地区趋势。","authors":"Raymond J So, Kimberley S Noij, Jiangxia Wang, Jonathan Walsh, Christine G Gourin, Carolyn M Jenks","doi":"10.1002/ohn.1107","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To analyze temporal changes and to assess the possible effect of newborn hearing screening (NBHS) programs on changes in congenital cytomegalovirus (cCMV) diagnostic rates in the United States.</p><p><strong>Study design: </strong>Cross-sectional study.</p><p><strong>Setting: </strong>National Inpatient Sample (NIS) database.</p><p><strong>Methods: </strong>Neonates with cCMV infection were identified using discharge data from the NIS database from 1998 to 2019. Neonates with cCMV infection were identified via International Classification of Diseases codes and categorized as asymptomatic versus symptomatic and with or without hearing loss. Linear regression and interrupted time series analyses were conducted to analyze changes in diagnostic rates over time. Interrupted analyses were based on the timing of NBHS implementation in geographic regions.</p><p><strong>Results: </strong>Per 1,000,000 live births, the estimated total number of cCMV diagnoses increased from 109 in 1998 to 250 in 2019 (the estimated annual increase per 1,000,000 live births is 6.89 ([95% confidence interval, 5.43-8.35], P < .001). Diagnosis of cCMV with hearing loss showed a significant annual increase during this time (0.87 [0.51-1.22], P < .001), and within this group, diagnosis of both asymptomatic (0.18 [0.03-0.32], P = .02) and symptomatic (0.68 [0.37-0.99], P < .001) cases increased significantly. Compared to pre-NBHS, the rate of increase in cCMV diagnosis was significantly higher post-NBHS implementation in the Northeast (P < .001) and South (P = .008).</p><p><strong>Conclusion: </strong>Implementation of state NBHS programs correlated with increasing diagnosis rates of cCMV, though cCMV education and awareness may be contributing. cCMV continues to be underdiagnosed in a large national database.</p>","PeriodicalId":19707,"journal":{"name":"Otolaryngology- Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"National and Regional Trends in Congenital Cytomegalovirus Infection From 1998 to 2019.\",\"authors\":\"Raymond J So, Kimberley S Noij, Jiangxia Wang, Jonathan Walsh, Christine G Gourin, Carolyn M Jenks\",\"doi\":\"10.1002/ohn.1107\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To analyze temporal changes and to assess the possible effect of newborn hearing screening (NBHS) programs on changes in congenital cytomegalovirus (cCMV) diagnostic rates in the United States.</p><p><strong>Study design: </strong>Cross-sectional study.</p><p><strong>Setting: </strong>National Inpatient Sample (NIS) database.</p><p><strong>Methods: </strong>Neonates with cCMV infection were identified using discharge data from the NIS database from 1998 to 2019. Neonates with cCMV infection were identified via International Classification of Diseases codes and categorized as asymptomatic versus symptomatic and with or without hearing loss. Linear regression and interrupted time series analyses were conducted to analyze changes in diagnostic rates over time. Interrupted analyses were based on the timing of NBHS implementation in geographic regions.</p><p><strong>Results: </strong>Per 1,000,000 live births, the estimated total number of cCMV diagnoses increased from 109 in 1998 to 250 in 2019 (the estimated annual increase per 1,000,000 live births is 6.89 ([95% confidence interval, 5.43-8.35], P < .001). Diagnosis of cCMV with hearing loss showed a significant annual increase during this time (0.87 [0.51-1.22], P < .001), and within this group, diagnosis of both asymptomatic (0.18 [0.03-0.32], P = .02) and symptomatic (0.68 [0.37-0.99], P < .001) cases increased significantly. Compared to pre-NBHS, the rate of increase in cCMV diagnosis was significantly higher post-NBHS implementation in the Northeast (P < .001) and South (P = .008).</p><p><strong>Conclusion: </strong>Implementation of state NBHS programs correlated with increasing diagnosis rates of cCMV, though cCMV education and awareness may be contributing. cCMV continues to be underdiagnosed in a large national database.</p>\",\"PeriodicalId\":19707,\"journal\":{\"name\":\"Otolaryngology- Head and Neck Surgery\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-01-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Otolaryngology- Head and Neck Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/ohn.1107\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OTORHINOLARYNGOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Otolaryngology- Head and Neck Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/ohn.1107","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
National and Regional Trends in Congenital Cytomegalovirus Infection From 1998 to 2019.
Objective: To analyze temporal changes and to assess the possible effect of newborn hearing screening (NBHS) programs on changes in congenital cytomegalovirus (cCMV) diagnostic rates in the United States.
Study design: Cross-sectional study.
Setting: National Inpatient Sample (NIS) database.
Methods: Neonates with cCMV infection were identified using discharge data from the NIS database from 1998 to 2019. Neonates with cCMV infection were identified via International Classification of Diseases codes and categorized as asymptomatic versus symptomatic and with or without hearing loss. Linear regression and interrupted time series analyses were conducted to analyze changes in diagnostic rates over time. Interrupted analyses were based on the timing of NBHS implementation in geographic regions.
Results: Per 1,000,000 live births, the estimated total number of cCMV diagnoses increased from 109 in 1998 to 250 in 2019 (the estimated annual increase per 1,000,000 live births is 6.89 ([95% confidence interval, 5.43-8.35], P < .001). Diagnosis of cCMV with hearing loss showed a significant annual increase during this time (0.87 [0.51-1.22], P < .001), and within this group, diagnosis of both asymptomatic (0.18 [0.03-0.32], P = .02) and symptomatic (0.68 [0.37-0.99], P < .001) cases increased significantly. Compared to pre-NBHS, the rate of increase in cCMV diagnosis was significantly higher post-NBHS implementation in the Northeast (P < .001) and South (P = .008).
Conclusion: Implementation of state NBHS programs correlated with increasing diagnosis rates of cCMV, though cCMV education and awareness may be contributing. cCMV continues to be underdiagnosed in a large national database.
期刊介绍：
Otolaryngology–Head and Neck Surgery (OTO-HNS) is the official peer-reviewed publication of the American Academy of Otolaryngology–Head and Neck Surgery Foundation. The mission of Otolaryngology–Head and Neck Surgery is to publish contemporary, ethical, clinically relevant information in otolaryngology, head and neck surgery (ear, nose, throat, head, and neck disorders) that can be used by otolaryngologists, clinicians, scientists, and specialists to improve patient care and public health.
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