血液透析患者血清鸢尾素水平与身体活动能力呈正相关。

IF 2.3 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Kidney & blood pressure research Pub Date : 2025-01-01 Epub Date: 2025-01-03 DOI:10.1159/000543214

Zhengjia Fan, Feng Wu, Peixin Wang, Leiyun Wu, Jialing Zhang, Wen Li, Qi Pang, Aihua Zhang

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引用次数: 0

摘要

有规律的身体活动对健康有益，但在接受维持性血液透析治疗的患者中往往会减少。鸢尾素是一种肌肉分泌激素，据报道可以改善新陈代谢，减缓一些慢性疾病的进展。本研究旨在探讨血液透析患者体力活动能力与血清鸢尾素水平的关系。方法：选取首都医科大学宣武医院血液透析患者252例。采用酶联免疫吸附法测定血中鸢尾素水平。采用生物电阻抗法分析体成分。采用国际身体活动问卷（IPAQ）对身体活动能力进行评分。结果：双变量相关分析显示IPAQ评分与irisin (irisin的自然对数；r = 0.326, P < 0.001)。IPAQ评分的独立决定因素是鸢尾素、年龄、空腹血糖和二氧化碳结合力。结论：我们的研究结果首次提供了血液透析患者血清鸢尾素水平与身体活动能力正相关的临床证据。

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Serum Irisin Levels Are Positively Correlated with Physical Activity Capacity in Hemodialysis Patients.

Introduction: Regular physical activity is beneficial for health but is often reduced in patients receiving maintenance hemodialysis treatment. Irisin is a muscle-secreted hormone that reportedly improves metabolism and slows down the progression of some chronic diseases. In this study, we aimed to investigate the relationship between physical activity capacity and serum irisin levels in hemodialysis patients.

Methods: Our study included 252 patients undergoing hemodialysis at Xuanwu Hospital Capital Medical University. Enzyme-linked immunosorbent assay was used to measure blood irisin levels. Body composition was analyzed by bioelectrical impedance analysis. The International Physical Activity Questionnaire (IPAQ) was used to score physical activity ability.

Results: Bivariate correlation analysis showed a positive correlation between IPAQ scores and ln irisin (the natural logarithm of irisin; r = 0.326, p < 0.001). Independent determinants of IPAQ scores were ln irisin, age, fasting glucose, and carbon dioxide combining power.

Conclusion: Our findings provide the first clinical evidence that serum irisin levels are positively correlated with physical activity capacity in hemodialysis patients.

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来源期刊

Kidney & blood pressure research 医学-泌尿学与肾脏学

CiteScore

4.80

自引率

3.60%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal comprises both clinical and basic studies at the interface of nephrology, hypertension and cardiovascular research. The topics to be covered include the structural organization and biochemistry of the normal and diseased kidney, the molecular biology of transporters, the physiology and pathophysiology of glomerular filtration and tubular transport, endothelial and vascular smooth muscle cell function and blood pressure control, as well as water, electrolyte and mineral metabolism. Also discussed are the (patho)physiology and (patho) biochemistry of renal hormones, the molecular biology, genetics and clinical course of renal disease and hypertension, the renal elimination, action and clinical use of drugs, as well as dialysis and transplantation. Featuring peer-reviewed original papers, editorials translating basic science into patient-oriented research and disease, in depth reviews, and regular special topic sections, ''Kidney & Blood Pressure Research'' is an important source of information for researchers in nephrology and cardiovascular medicine.