Paola Zuluaga, Coral Zurera-Egea, Daniel Fuster, Anna Hernandez-Rubio, Aina Teniente-Serra, Eva Martínez-Cáceres, Roberto Muga
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引用次数: 0
摘要
酒精相关性肝硬化（AC）是一种影响免疫力的疾病。我们分析了ac患者CD4+亚群随时间的变化。我们纳入了至少两次入院接受治疗的酒精使用障碍患者。无肝脏疾病证据的患者为对照组（CG）。我们分析了naïve、memory、TEMRA、Th1、Th2、Th17、早期激活和晚期激活的子集。随访期间，ac组（n = 5）患者TEMRA T细胞增加（1.2±1.1%比2.1±1.1%,p = 0.03）， CG组（n = 22）患者Th17细胞减少（14.1±4.3%比12.3±6.4%,p = 0.03）。在两组中，晚激活的细胞与记忆细胞的减少有关。这种相关性在ac患者中更强（r = - 0.90, p = 0.04）。记忆细胞比例与大鼠CG中Th1/Th2/Th17细胞数量增加相关(r = 0.70, r = 0.68, r = 0.63；P +微分。
Changes in CD4+ T cells subsets in patients with alcohol-related cirrhosis.
Alcohol-related cirrhosis (AC) is a condition that impacts in immunity. We analyzed changes over time in CD4+subsets in AC-patients. We included patients with alcohol use disorder admitted at least twice for treatment. Patients without evidence of liver disease were the control group (CG). We analyzed naïve, memory, TEMRA, Th1, Th2, Th17, early activated, and late activated subsets. During the follow-up, TEMRA T cells were increased (1.2 ± 1.1% vs. 2.1 ± 1.1%, p = 0.03) in AC-patients (n = 5) and Th17 cells were decreased (14.1 ± 4.3% vs. 12.3 ± 6.4%, p = 0.03) in the CG (n = 22). Late activated cells were associated with a decrease in memory cells in both the groups. This association was stronger in AC-patients (r = - 0.90, p = 0.04). The proportion of memory cells was correlated with an increased of Th1/Th2/Th17 cells in the CG (r = 0.70, r = 0.68, r = 0.63; p < 0.01, respectively), whereas in AC-patients was correlated with a decrease in Th17 cells (r = - 0.90, p = 0.03). AC-patients showed an increase in the proportion of TEMRA T cells, loss of heterogeneity and decreased CD4+ differentiation.
期刊介绍：
Clinical and Experimental Medicine (CEM) is a multidisciplinary journal that aims to be a forum of scientific excellence and information exchange in relation to the basic and clinical features of the following fields: hematology, onco-hematology, oncology, virology, immunology, and rheumatology. The journal publishes reviews and editorials, experimental and preclinical studies, translational research, prospectively designed clinical trials, and epidemiological studies. Papers containing new clinical or experimental data that are likely to contribute to changes in clinical practice or the way in which a disease is thought about will be given priority due to their immediate importance. Case reports will be accepted on an exceptional basis only, and their submission is discouraged. The major criteria for publication are clarity, scientific soundness, and advances in knowledge. In compliance with the overwhelmingly prevailing request by the international scientific community, and with respect for eco-compatibility issues, CEM is now published exclusively online.
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