Leonard Knoedler, Martin Kauke-Navarro, Samuel Knoedler, Tobias Niederegger, Elena Hofmann, Max Heiland, Steffen Koerdt, Susanne Nahles, Helena Baecher
{"title":"面部移植受者的口腔健康和康复——系统综述。","authors":"Leonard Knoedler, Martin Kauke-Navarro, Samuel Knoedler, Tobias Niederegger, Elena Hofmann, Max Heiland, Steffen Koerdt, Susanne Nahles, Helena Baecher","doi":"10.1007/s00784-024-06078-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Facial transplantation (FT) provides advanced solutions for severe facial defects by incorporating complex tissues such as bone, skin, oral mucosa and nerves. Oral health plays a critical role in FT, impacting both functional outcomes and transplant prognosis. Despite its importance, literature on oral health in FT recipients remains sparse.</p><p><strong>Methods: </strong>This systematic review adhered to PRISMA guidelines. We searched PubMed, EMBASE, Web of Science, and CENTRAL for studies on oral health in FT patients up to August 4, 2024. Eligible studies were evaluated using the Newcastle-Ottawa Scale (NOS) and Level of Evidence (LOE). Data extracted included study design, general information on FT, patient demographics, oral examination techniques, and outcomes.</p><p><strong>Results: </strong>Out of 6,984 articles reviewed, 19 met the inclusion criteria, all consisting of case reports or case series involving 48 FT cases. Of these, 25 cases provided relevant oral health and rehabilitation data. All studies showed a LOE of IV, with an average NOS score of 4.3 ± 0.5. Most FT cases involved male recipients (n = 20, 80%), while the majority of FTs were conducted in the United States (n = 10, 40%) and France (n = 7, 28%). Oral mucosa biopsy was the most common examination method (n = 11, 44%). Malocclusion was reported in 48% (n = 12) of cases, with revision surgeries occurring in 36% (n = 9). Post-FT dental treatments included tooth extractions (n = 7, 28%), fillings (n = 3, 12%), and endodontic treatments (n = 2, 8%). Dental implants were placed in 32% (n = 8) of cases, with one case (4%) reporting failed osseointegration.</p><p><strong>Conclusion: </strong>Routine oral health assessments are essential for FT patients to prevent complications and improve clinical outcomes. However, there is a lack of high-quality research on oral health in FT recipients, underscoring the need for further studies to establish standardized care protocols.</p><p><strong>Clinical relevance: </strong>This review emphasizes the urgent need for standardized oral health protocols in FT patients to minimize infection risks and optimize long-term transplant success and overall patient health.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"47"},"PeriodicalIF":3.1000,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11703954/pdf/","citationCount":"0","resultStr":"{\"title\":\"Oral health and rehabilitation in face transplant recipients - a systematic review.\",\"authors\":\"Leonard Knoedler, Martin Kauke-Navarro, Samuel Knoedler, Tobias Niederegger, Elena Hofmann, Max Heiland, Steffen Koerdt, Susanne Nahles, Helena Baecher\",\"doi\":\"10.1007/s00784-024-06078-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Facial transplantation (FT) provides advanced solutions for severe facial defects by incorporating complex tissues such as bone, skin, oral mucosa and nerves. Oral health plays a critical role in FT, impacting both functional outcomes and transplant prognosis. Despite its importance, literature on oral health in FT recipients remains sparse.</p><p><strong>Methods: </strong>This systematic review adhered to PRISMA guidelines. We searched PubMed, EMBASE, Web of Science, and CENTRAL for studies on oral health in FT patients up to August 4, 2024. Eligible studies were evaluated using the Newcastle-Ottawa Scale (NOS) and Level of Evidence (LOE). Data extracted included study design, general information on FT, patient demographics, oral examination techniques, and outcomes.</p><p><strong>Results: </strong>Out of 6,984 articles reviewed, 19 met the inclusion criteria, all consisting of case reports or case series involving 48 FT cases. Of these, 25 cases provided relevant oral health and rehabilitation data. All studies showed a LOE of IV, with an average NOS score of 4.3 ± 0.5. Most FT cases involved male recipients (n = 20, 80%), while the majority of FTs were conducted in the United States (n = 10, 40%) and France (n = 7, 28%). Oral mucosa biopsy was the most common examination method (n = 11, 44%). Malocclusion was reported in 48% (n = 12) of cases, with revision surgeries occurring in 36% (n = 9). Post-FT dental treatments included tooth extractions (n = 7, 28%), fillings (n = 3, 12%), and endodontic treatments (n = 2, 8%). Dental implants were placed in 32% (n = 8) of cases, with one case (4%) reporting failed osseointegration.</p><p><strong>Conclusion: </strong>Routine oral health assessments are essential for FT patients to prevent complications and improve clinical outcomes. However, there is a lack of high-quality research on oral health in FT recipients, underscoring the need for further studies to establish standardized care protocols.</p><p><strong>Clinical relevance: </strong>This review emphasizes the urgent need for standardized oral health protocols in FT patients to minimize infection risks and optimize long-term transplant success and overall patient health.</p>\",\"PeriodicalId\":10461,\"journal\":{\"name\":\"Clinical Oral Investigations\",\"volume\":\"29 1\",\"pages\":\"47\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-01-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11703954/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Oral Investigations\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00784-024-06078-3\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Oral Investigations","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00784-024-06078-3","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Oral health and rehabilitation in face transplant recipients - a systematic review.
Background: Facial transplantation (FT) provides advanced solutions for severe facial defects by incorporating complex tissues such as bone, skin, oral mucosa and nerves. Oral health plays a critical role in FT, impacting both functional outcomes and transplant prognosis. Despite its importance, literature on oral health in FT recipients remains sparse.
Methods: This systematic review adhered to PRISMA guidelines. We searched PubMed, EMBASE, Web of Science, and CENTRAL for studies on oral health in FT patients up to August 4, 2024. Eligible studies were evaluated using the Newcastle-Ottawa Scale (NOS) and Level of Evidence (LOE). Data extracted included study design, general information on FT, patient demographics, oral examination techniques, and outcomes.
Results: Out of 6,984 articles reviewed, 19 met the inclusion criteria, all consisting of case reports or case series involving 48 FT cases. Of these, 25 cases provided relevant oral health and rehabilitation data. All studies showed a LOE of IV, with an average NOS score of 4.3 ± 0.5. Most FT cases involved male recipients (n = 20, 80%), while the majority of FTs were conducted in the United States (n = 10, 40%) and France (n = 7, 28%). Oral mucosa biopsy was the most common examination method (n = 11, 44%). Malocclusion was reported in 48% (n = 12) of cases, with revision surgeries occurring in 36% (n = 9). Post-FT dental treatments included tooth extractions (n = 7, 28%), fillings (n = 3, 12%), and endodontic treatments (n = 2, 8%). Dental implants were placed in 32% (n = 8) of cases, with one case (4%) reporting failed osseointegration.
Conclusion: Routine oral health assessments are essential for FT patients to prevent complications and improve clinical outcomes. However, there is a lack of high-quality research on oral health in FT recipients, underscoring the need for further studies to establish standardized care protocols.
Clinical relevance: This review emphasizes the urgent need for standardized oral health protocols in FT patients to minimize infection risks and optimize long-term transplant success and overall patient health.
期刊介绍：
The journal Clinical Oral Investigations is a multidisciplinary, international forum for publication of research from all fields of oral medicine. The journal publishes original scientific articles and invited reviews which provide up-to-date results of basic and clinical studies in oral and maxillofacial science and medicine. The aim is to clarify the relevance of new results to modern practice, for an international readership. Coverage includes maxillofacial and oral surgery, prosthetics and restorative dentistry, operative dentistry, endodontics, periodontology, orthodontics, dental materials science, clinical trials, epidemiology, pedodontics, oral implant, preventive dentistiry, oral pathology, oral basic sciences and more.
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