功能性消化不良患者胃黏膜神经密度降低：临床意义及功能相关性。

IF 8 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

American Journal of Gastroenterology Pub Date : 2025-01-06 DOI:10.14309/ajg.0000000000003296

Yao-Chun Yang, Ping-Huei Tseng, Chieh-Chang Chen, Ya-Yin Cheng, Jing-Jung Wei, Cheng-Chen Lin, Ti-Yen Yeh, Chi-Chao Chao, Sung-Tsang Hsieh

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引用次数: 0

摘要

背景：本研究旨在定量检测功能性消化不良（FD）患者胃粘膜神经密度（GMND）并分析其临床相关性。方法：我们前瞻性地招募了35例FD患者和16例年龄和性别匹配的健康对照者，比较内镜活检、胃轻瘫主要症状指数（GCSI）评分和胃排空造影（GES）的GMND。结果：FD患者胃窦、胃体、胃底的GMND均低于对照组。GMND与GCSI评分呈负相关，与GES参数不相关。结论：FD患者GMND降低，且与症状严重程度呈负相关。

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Reduced gastric mucosal nerve density in functional dyspepsia: clinical significance and functional correlation.

Background: This study aimed to quantitatively examine gastric mucosal nerve density (GMND) in patients with functional dyspepsia (FD) and analyzed its clinical correlation.

Methods: We prospectively enrolled 35 patients with FD and 16 age-and gender-matched healthy controls for comparison of GMND on endoscopic biopsy, scores of Gastroparesis Cardinal Symptom Index (GCSI), and gastric emptying scintigraphy (GES).

Results: Patients with FD had lower GMND than the control subjects in gastric antrum, body, and fundus. GMND was inversely correlated with the GCSI scores, but not correlated with GES parameters.

Conclusion: GMND was reduced in FD and inversely correlated with the symptom severity.

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来源期刊

American Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

11.40

自引率

5.10%

发文量

458

审稿时长

12 months

期刊介绍： Published on behalf of the American College of Gastroenterology (ACG), The American Journal of Gastroenterology (AJG) stands as the foremost clinical journal in the fields of gastroenterology and hepatology. AJG offers practical and professional support to clinicians addressing the most prevalent gastroenterological disorders in patients.