内源电场调控种植体周围电荷微环境促进骨整合。

IF 10 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Fangfang Xu, Guangbin Zhao, Yuxin Gong, Xiang Liang, Ming Yu, Hao Cui, Linyang Xie, Nan Zhu, Xuan Zhu, Xiaoxi Shao, Kun Qi, Bingheng Lu, Junbo Tu, Sijia Na
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引用次数: 0

摘要

调节植入物周围的带电微环境是促进骨结合的有效方法。虽然带电微环境的平衡在组织中起着不可或缺的作用,但目前的研究都是外部侵入性的,不适合临床应用。本研究通过改变钽和银在 Ti-6Al-4V 合金(TC4)表面的空间布局,制备了具有不同表面电位差的功能材料。这种材料在体内植入后与带负电荷的细胞膜自然形成内生电场(EEF),并通过上调 Ca2+ 浓度和激活后续通路促进骨与植入物界面的骨结合。有趣的是,促进干细胞分化、调节免疫细胞极化方向和抗菌功效是由植入物所含的自由电荷决定的,而不是由表面电位差的大小决定的。这种功能性种植体代表了一种调节种植体周围带电微环境和增强骨结合的独特策略,从而为新型种植体材料的临床开发提供了思路和技术方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Enhancement of Osseointegration via Endogenous Electric Field by Regulating the Charge Microenvironments around Implants.

The regulation of the charged microenvironment around implants is an effective way to promote osseointegration. Although homeostasis of the charged microenvironment plays an integral role in tissues, current research is externally invasive and unsuitable for clinical applications. In this study, functional materials with different surface potential differences are prepared by changing the spatial layout of Ta and Ag on the surface of a Ti-6Al-4V alloy (TC4). This naturally formed an endogenous electric field (EEF) with a negatively charged cell membrane after in vivo implantation and promoted osseointegration at the interface between the bone and implant through the upregulation of Ca2+ concentration and activation of subsequent pathways. Interestingly, the promotion of stem cell differentiation, regulation of the direction of immune cell polarization, and antibacterial efficacy are determined by the free charge contained in the implant, rather than by the magnitude of the surface potential difference. This functional implant represents a unique strategy for regulating the charged microenvironment around the implant and enhancing osseointegration, thereby providing ideas and technical approaches for the clinical development of novel implant materials.

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来源期刊
Advanced Healthcare Materials
Advanced Healthcare Materials 工程技术-生物材料
CiteScore
14.40
自引率
3.00%
发文量
600
审稿时长
1.8 months
期刊介绍: Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.
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