临床试验网站上登记的复发性自然流产的情况。

IF 3.9 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Frontiers in Endocrinology Pub Date : 2024-12-20 eCollection Date: 2024-01-01 DOI:10.3389/fendo.2024.1460968
Xiaoling Zhou, Fan Lai, Wei Chen, Congrong Zhou, Yi Deng, Tao Wang, Shasha Xing, Haoyang Diao, Mi Tang, Wenmei Guo, Erdan Luo
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引用次数: 0

摘要

目的:复发性自然流产(RSA)是生殖医学领域的一个重大挑战,尽管进行了广泛的研究,但有效的治疗方法仍然有限。全面了解当前的RSA临床试验对于加强试验设计和确定现有的研究差距至关重要。本研究的目的是描述在clinical trials .gov上注册的RSA相关临床试验的特征。方法:进行了彻底的搜索,以识别和审查截至2024年3月2日在clinical trials .gov上注册的RSA相关临床试验。结果:本分析共纳入138项试验,其中干预试验72项(52.17%),观察试验66项(47.83%)。大约一半的研究(67,48.55%)的入组人数为100人或更少。大多数试验只包括女性参与者。亚洲的临床试验数量最多(46项,33.33%),其次是欧洲(36项,26.09%)、非洲(29项,21.01%)、美洲(13项,9.42%)。大多数试验(61,44.20%)集中于不明原因复发性自然流产(URSA)的个体。在回顾的研究中,主要的干预类型是药物干预(49,62.82%),行为干预试验显著增加。结论:我们的研究结果表明,目前在RSA领域的研究工作不足以促进预防和治疗策略的发展。大多数临床试验主要针对URSA患者,特别强调药物干预,特别是抗凝血剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The landscape of recurrent spontaneous abortion registered on clinical trials.gov.

Objective: Recurrent spontaneous abortion (RSA) presents a significant challenge in the field of reproductive medicine, as effective treatments remain limited despite extensive research efforts. A comprehensive understanding of current RSA clinical trials is essential for enhancing trial design and identifying existing research gaps. The aim of this study is to characterize RSA related clinical trials registered on Clinical Trials.gov.

Methods: A thorough search was conducted to identify and review clinical trials focusing on RSA that were registered on Clinical Trials.gov up to March2, 2024.

Results: A total of 138 trials were identified in the analysis, with 72 (52.17%) classified as intervention trials and 66 (47.83%) as observational trials. Approximately half of the studies (67,48.55%) had an enrollment of 100 participants or fewer. The majority of trials included only female participants. Asia hosted the highest number of clinical trials (46,33.33%), followed by Europe (36,26.09%), Africa (29,21.01%), America (13,9.42%). The majority of trials (61,44.20%) focused on individuals with unexplained recurrent spontaneous abortion (URSA). The predominant intervention types examined in the reviewed studies were drug interventions (49,62.82%), with a notable rise in behavioral intervention trials.

Conclusion: Our research findings suggest that existing research efforts in the realm of RSA are inadequate for the progression of prevention and treatment strategies. The majority of clinical trials have primarily targeted individuals with URSA, with a particular emphasis on drug interventions, notably anticoagulants.

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来源期刊
Frontiers in Endocrinology
Frontiers in Endocrinology Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
5.70
自引率
9.60%
发文量
3023
审稿时长
14 weeks
期刊介绍: Frontiers in Endocrinology is a field journal of the "Frontiers in" journal series. In today’s world, endocrinology is becoming increasingly important as it underlies many of the challenges societies face - from obesity and diabetes to reproduction, population control and aging. Endocrinology covers a broad field from basic molecular and cellular communication through to clinical care and some of the most crucial public health issues. The journal, thus, welcomes outstanding contributions in any domain of endocrinology. Frontiers in Endocrinology publishes articles on the most outstanding discoveries across a wide research spectrum of Endocrinology. The mission of Frontiers in Endocrinology is to bring all relevant Endocrinology areas together on a single platform.
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