Soyal Sabu, Padinjare Veetil Saranya and Gopinathan Anilkumar
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An overview of palladium-catalyzed N-alkylation reactions
N-Alkylation of amines is a vital reaction in the synthesis of numerous bioactive compounds and materials. Among transition metals, palladium has emerged as a particularly effective catalyst for these transformations. The unique advantages of palladium arise from its superior catalytic efficiency, ability to operate under mild conditions, high selectivity and recyclability. Additionally, palladium facilitates the borrowing hydrogen methodology, offering sustainable and environmentally friendly alternatives. This review covers advancements in palladium-catalyzed N-alkylation reactions. The mechanistic insights and practical applications are discussed, providing a comprehensive overview of the current state of research and future directions in this field, covering literature up to 2024.
期刊介绍：
Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.
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