通过共结晶探索曼德拉酰胺的晶体景观和手性分辨率。

IF 3.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Crystal Growth & Design Pub Date : 2024-12-10 eCollection Date: 2025-01-01 DOI:10.1021/acs.cgd.3c01513

Shan Huang, Deirbhile Fitzgerald, Samuel A Koledoye, Stuart G Collins, Anita R Maguire, Simon E Lawrence

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引用次数: 0

摘要

测定了（±）-曼德酰胺、S-曼德酰胺和对映体富集曼德酰胺（94 S: 6 R）的晶体结构。合成了含有扁桃酸和脯氨酸对映体的s -扁桃酰胺非对映体共晶对。S-曼德酰胺与S/ r -曼德酸的非对映体共晶对在每种情况下均形成1:1的共晶对，而S-曼德酰胺与脯氨酸的非对映体共晶对具有不同的化学计量。对这种非对映异构体共晶体系进行手性分辨的初步研究显示了前景。

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Exploring the Crystal Landscape of Mandelamide and Chiral Resolution via Cocrystallization.

The crystal structures of (±)-mandelamide, S-mandelamide, and enantioenriched mandelamide (94 S : 6 R) were determined. Diastereomeric cocrystal pairs of S-mandelamide with both enantiomers of mandelic acid and proline were synthesized. The diastereomeric cocrystal pairs of S-mandelamide with S/R-mandelic acid form 1:1 cocrystals in each case, while the diastereomeric cocrystal pairs of S-mandelamide with proline have different stoichiometries. Preliminary investigation of this diastereomeric cocrystal system for chiral resolution shows promise.

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来源期刊

Crystal Growth & Design 化学-材料科学：综合

CiteScore

6.30

自引率

10.50%

发文量

650

审稿时长

1.9 months

期刊介绍： The aim of Crystal Growth & Design is to stimulate crossfertilization of knowledge among scientists and engineers working in the fields of crystal growth, crystal engineering, and the industrial application of crystalline materials. Crystal Growth & Design publishes theoretical and experimental studies of the physical, chemical, and biological phenomena and processes related to the design, growth, and application of crystalline materials. Synergistic approaches originating from different disciplines and technologies and integrating the fields of crystal growth, crystal engineering, intermolecular interactions, and industrial application are encouraged.