肺移植患者的毛霉菌病感染：西班牙安达卢西亚的经验。

IF 0.8 4区医学 Q4 IMMUNOLOGY

Transplantation proceedings Pub Date : 2025-01-01 DOI:10.1016/j.transproceed.2024.11.030

Alba María Fernández González , Ninoska Moreira Lorenzo , Benito Cantador Huertos , Manuel Causse Del Río , Francisco Javier González García , Antonio Álvarez Kindelan

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引用次数: 0

摘要

肺移植（LT）患者气道粘膜感染是罕见的，但在移植肺中的发病率正在上升。目的：介绍毛霉病术后立即感染的LT治疗经验。方法：回顾2000年至2023年间在安达卢西亚进行的767例LT，通过微生物学结果和组织学结果鉴定毛霉菌。结果：Mucorales的发生率低于我院所有LTs的1%，但死亡率为100%。在我们的研究中，所有慢性阻塞性肺疾病的病例都接受了肝移植。他们表现为肺部感染并发展为播散性感染。主要相关危险因素包括既往皮质类固醇治疗、营养不良、实体器官移植、单肺移植、免疫抑制和伴随的曲霉感染。结论：肺移植术后移植物毛霉菌感染是一种致死性并发症，文献记载甚少。对这些患者保持警惕对早期诊断至关重要。

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Mucormycosis Infection in Lung Transplant Patients: Experience in Andalusia, Spain

Introduction

Mucorales infections in the airways of lung transplant (LT) patients are rare but have a rising incidence in transplanted lungs.

Objective

We present our experience with LT in immediate postoperative infections due to mucormycosis.

Methods

Review of 767 LT performed in Andalusia between 2000 and 2023 identifying Mucorales through microbiological results and histological findings.

Results

The incidence of Mucorales was less than 1% of all LTs performed at our institution but resulted in 100% mortality. In our series, all cases underwent LT for chronic obstructive pulmonary disease. They presented with pulmonary infection that progressed to disseminated infection. Major associated risk factors included prior corticosteroid treatment, malnutrition, solid organ transplantation, single lung transplantation, immunosuppression, and concomitant Aspergillus infection.

Conclusions

Mucormycosis infection in grafts after lung transplantation is a lethal complication poorly documented in the literature. Vigilance for Mucorales in these patients is crucial for early diagnosis.

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来源期刊

Transplantation proceedings 医学-免疫学

CiteScore

1.70

自引率

0.00%

发文量

502

审稿时长

60 days

期刊介绍： Transplantation Proceedings publishes several different categories of manuscripts, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. The first type of manuscripts consists of sets of papers providing an in-depth expression of the current state of the art in various rapidly developing components of world transplantation biology and medicine. These manuscripts emanate from congresses of the affiliated transplantation societies, from Symposia sponsored by the Societies, as well as special Conferences and Workshops covering related topics. Transplantation Proceedings also publishes several special sections including publication of Clinical Transplantation Proceedings, being rapid original contributions of preclinical and clinical experiences. These manuscripts undergo review by members of the Editorial Board. Original basic or clinical science articles, clinical trials and case studies can be submitted to the journal?s open access companion title Transplantation Reports.