pdd引导下肿瘤切除联合光动力治疗皮肤鳞状细胞癌的疗效观察。

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-02-01 DOI:10.1016/j.pdpdt.2024.104469

Nan Yang , Yunchuan Yang , Wanqi Zhang, Xinying Li, Hao Jiang, Huiling Kou, Junbo Zhang, Yuanyuan Wang, Liuchang Tan, Yuangang Lu

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引用次数: 0

摘要

背景：皮肤鳞状细胞癌（cSCC）是一种边界不清的侵袭性肿瘤。光动力诊断（PDD）能够通过可见荧光将肿瘤组织与正常组织区分开来。光动力疗法（PDT）广泛应用于非黑色素瘤皮肤肿瘤的治疗。本研究旨在阐明pdd引导下肿瘤切除联合ALA-PDT治疗cSCC患者的有效性和安全性。方法：本研究纳入23例cSCC患者，随机分为PDD组（n=11）和非PDD组（n=12）。PDD组患者在PDD指导下行肿瘤切除，非PDD组患者行广域局部切除（wide local resection， WLE）。两组均行冰冻切片分析，术中及术后均行PDT。结果：PDD组的阴性切缘率为98.6%，明显高于非PDD组的69.2%。PDD组需要较少的冷冻切片分析和缩短的手术时间。结论：PDD能有效地描绘cSCC的肿瘤边缘，指导手术切除范围。pdd引导切除与PDT相结合为cSCC提供了一种高度安全有效的治疗策略。

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Efficacy of PDD-guided tumor excision combined with photodynamic therapy in cutaneous squamous cell carcinoma

Background

Cutaneous squamous cell carcinoma (cSCC) is an aggressive tumor with unclear margins. Photodynamic diagnosis (PDD) enables the differentiation of tumor tissue from normal tissue via visible fluorescence. Photodynamic therapy (PDT) is widely used in the treatment of non-melanoma skin tumors. This study aims to illustrate the efficacy and safety of PDD-guided tumor excision combined with ALA-PDT in patients with cSCC.

Methods

This study involved 23 cSCC patients, randomly assigned to the PDD group (n = 11) and the non-PDD group (n = 12). Patients in the PDD group underwent tumor excision guided by PDD, while those in the non-PDD group received wide local excision (WLE). Both groups were subjected to frozen section analysis, and PDT was applied during and post-surgery.

Results

The negative margin rate in the PDD group was 98.6 %, significantly higher than the 69.2 % observed in the non-PDD group. The PDD group required fewer frozen section analyses and experienced reduced surgical duration.

Conclusions

PDD effectively delineates tumor margins in cSCC, guiding the scope of surgical excision. The integration of PDD-guided resection with PDT offers a highly safe and effective therapeutic strategy for cSCC.

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.