促黄体生成素受体缺乏在未成熟的卵母细胞复合体检索辅助生殖。

F&S science Pub Date : 2025-01-02 DOI:10.1016/j.xfss.2024.12.006

Maíra Casalechi, Maria Thereza V Pereira, Wiviane A Assis, Cynthia Dela Cruz, Tays F Guedes, Ines Katerina Cavallo, Fernando M Reis

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引用次数: 0

摘要

本研究探讨了促黄体生成素受体（LHR）在单个卵泡颗粒细胞中的表达是否随辅助生殖技术（ART）治疗卵母细胞成熟阶段的不同而变化。我们观察到在生发囊泡（GV）期卵母细胞周围的积云细胞中很少甚至没有LHR mRNA和蛋白的表达。有趣的是，它们的成熟能力被体外抢救成熟证实，这表明体细胞LHR缺陷是抗逆转录病毒治疗中恢复GV卵母细胞的关键因素。

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Luteinizing hormone receptor deficiency in immature cumulus-oocyte complexes retrieved for assisted reproduction.

This study investigated whether luteinizing hormone receptor (LHR) expression varies in the granulosa cells of individual follicles according to the maturation stage of the oocytes harvested for assisted reproductive technology treatment. We observed minimal to no LHR messenger ribonucleic acid and protein expression in cumulus cells surrounding oocytes arrested in the germinal vesicle stage. Interestingly, their ability to mature was confirmed by rescue in vitro maturation, suggesting somatic cell LHR deficiency as a key factor for the retrieval of germinal vesicle oocytes in assisted reproductive technology procedures.

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来源期刊

F&S science Endocrinology, Diabetes and Metabolism, Obstetrics, Gynecology and Women's Health, Urology

CiteScore

2.00

自引率

0.00%

发文量

审稿时长

51 days