分子手术刀解剖抗nmda受体脑炎GluN1新热点。

IF 17.6 1区医学 Q1 IMMUNOLOGY

Science Immunology Pub Date : 2025-01-03 DOI:10.1126/sciimmunol.adv4913

Marianna Spatola, Josep Dalmau

引用次数: 0

摘要

患者来源的NMDAR单克隆抗体结合单粒子冷冻电镜显示多个GluN1表位和不同的功能作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Molecular scalpels dissect new GluN1 hot spots in anti–NMDA receptor encephalitis

Patient-derived NMDAR mAbs combined with single-particle cryo-electron microscopy reveal multiple GluN1 epitopes and distinct functional effects.

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来源期刊

Science Immunology Immunology and Microbiology-Immunology

CiteScore

32.90

自引率

2.00%

发文量

183

期刊介绍： Science Immunology is a peer-reviewed journal that publishes original research articles in the field of immunology. The journal encourages the submission of research findings from all areas of immunology, including studies on innate and adaptive immunity, immune cell development and differentiation, immunogenomics, systems immunology, structural immunology, antigen presentation, immunometabolism, and mucosal immunology. Additionally, the journal covers research on immune contributions to health and disease, such as host defense, inflammation, cancer immunology, autoimmunity, allergy, transplantation, and immunodeficiency. Science Immunology maintains the same high-quality standard as other journals in the Science family and aims to facilitate understanding of the immune system by showcasing innovative advances in immunology research from all organisms and model systems, including humans.