福克斯洞察：早期帕金森病最令人烦恼的症状。

IF 2.6 4区医学 Q2 CLINICAL NEUROLOGY

Movement Disorders Clinical Practice Pub Date : 2025-01-03 DOI:10.1002/mdc3.14321

Aaron Lerner, Jennifer R Mammen, Mirinda Tyo, Peggy Auinger, Raunak Al-Rubayie, Yuge Xiao, Connie Marras, Jamie L Adams

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引用次数: 0

摘要

背景：关于早期帕金森病（PD）症状意义的证据有限。目的：利用Fox Insight研究中的帕金森病患者问题报告（PD- prop）问卷调查数据，确定早期PD患者经历的最麻烦的症状。方法：自我报告PD诊断的个体完成PD- prop问卷，报告多达五种最令人烦恼的症状。症状类型和频率是通过人类专业知识和机器学习相结合得出的。结果：参与者（N = 8536）为确诊0.9年，以白人（96%）为主，男性（53.3%），平均年龄64.6岁。最令人烦恼的运动症状是震颤（55.9%）和步态问题（36.7%）。最令人烦恼的非运动症状是疼痛/不适（33.1%）和身体疲劳（27.5%）。结论：本研究强调了早期PD症状的复杂性。未来需要考虑不同的患者经验，以改善治疗和结果测量策略。

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Fox Insight: Most Bothersome Symptoms in Early-Stage Parkinson's Disease.

Background: Limited evidence exists regarding the meaningfulness of symptoms experienced in early Parkinson's disease (PD).

Objectives: To identify the most bothersome symptoms experienced by people with early PD, leveraging data from the Parkinson's Disease Patient Report of Problems (PD-PROP) questionnaire within the Fox Insight Study.

Methods: Individuals with a self-reported diagnosis of PD completed the PD-PROP questionnaire, reporting up to five most bothersome symptoms. Symptom types and frequencies were derived through a combination of human expertise and machine learning.

Results: Participants (N = 8536) were 0.9 years since diagnosis, predominantly white (96%), male (53.3%), and with an average age of 64.6 years. Top most bothersome motor symptoms were tremor (55.9%) and gait issues (36.7%). Top most bothersome non-motor symptoms were pain/discomfort (33.1%) and physical fatigue (27.5%).

Conclusions: This study underscores the complexity of early PD symptomatology. Future consideration of diverse patient experiences is needed to improve therapeutic and outcome measurement strategies.

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来源期刊

Movement Disorders Clinical Practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

7.50%

发文量

218

期刊介绍： Movement Disorders Clinical Practice- is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/rarities), investigative (for e.g- genetics, imaging), translational (phenotype-genotype or other) and treatment aspects (clinical guidelines, diagnostic and treatment algorithms)