肠脂肪酸结合蛋白在胃肠道上皮损伤生物学中的潜在生物标志物研究。

IF 1.9 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current protein & peptide science Pub Date : 2025-01-01 DOI:10.2174/0113892037311290240930054913

Nahid Rehman, Anjana Pandey

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引用次数: 0

摘要

肠道损伤的诊断仍然是一个挑战，因为它是罕见的发生和发生在多个创伤患者。肠道损伤的延迟发现增加了多种风险，如败血症，许多器官衰竭以及死亡。在这篇综述中，我们证实了提出替代生物标志物的目标，这些生物标志物可以更轻松地测量肠道的渗透性。肠脂肪酸结合蛋白（I-FABP）仅在肠内表达，并在组织损伤时释放到细胞外。这项工作的重点是评估I-FABP作为区分腹部损伤和肠道损伤的初始生物标志物的合法性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Insight of Intestinal Fatty Acid Binding Protein as a Potential Biomarker in the Biology of Epithelial Damage of Gastrointestinal Membrane.

The diagnosis of intestinal injury remains a challenge as it is rare in occurrence and transpires in multiple traumatized patients. The deferred finding of injury of intestines upsurges multiple risks such as septicemia, numerous organ failures as well as mortality. In this review, we corroborate with the goals of proposing surrogate biomarkers that consent to the measurement of the permeability of intestines more effortlessly. The expression of intestinal fatty acid binding protein (I-FABP) is exclusive in the intestine and has beenreported to release extracellularly upon damage caused to tissues. This work focuses on evaluating the legitimacy of I-FABP as an initial biomarker to distinguish abdominal damage predominantly from an injury to the intestine.

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来源期刊

Current protein & peptide science 生物-生化与分子生物学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Current Protein & Peptide Science publishes full-length/mini review articles on specific aspects involving proteins, peptides, and interactions between the enzymes, the binding interactions of hormones and their receptors; the properties of transcription factors and other molecules that regulate gene expression; the reactions leading to the immune response; the process of signal transduction; the structure and function of proteins involved in the cytoskeleton and molecular motors; the properties of membrane channels and transporters; and the generation and storage of metabolic energy. In addition, reviews of experimental studies of protein folding and design are given special emphasis. Manuscripts submitted to Current Protein and Peptide Science should cover a field by discussing research from the leading laboratories in a field and should pose questions for future studies. Original papers, research articles and letter articles/short communications are not considered for publication in Current Protein & Peptide Science.