烯不对称环化的光诱导自由基二氧化硫插入：获得含s -立体中心环亚胺的β-手性砜

IF 10.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Science China Chemistry Pub Date : 2024-09-26 DOI:10.1007/s11426-024-2151-x

Jiapian Huang, Chenxin Wang, Xu Wang, Xiaoyu Zhou, Wei Xiao, Jie Wu

引用次数: 0

摘要

介绍了光氧化还原催化二氧化硫插入不对称自由基环化法制备各种含手性环亚胺的β-手性砜。该方法具有底物范围广、立体特异性强的特点。计算研究表明，亚砜基与CH2SO2Ph基之间的分散相互作用在立体选择性控制中起着至关重要的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Photoinduced radical sulfur dioxide insertion with asymmetric cyclization of alkenes: accessing β-chiral sulfones bearing S-stereocentric cyclic sulfinamides

The generation of various β-chiral sulfones bearing chiral cyclic sulfinamides through photoredox-catalyzed sulfur dioxide insertion with asymmetric radical cyclization is described. This method features a broad substrate scope and excellent stereo-specificity. Computational studies reveal that the dispersion interaction between sulfinyl group and CH₂SO₂Ph group plays a crucial role in the stereoselectivity control.

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来源期刊

Science China Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

14.40

自引率

7.30%

发文量

3787

审稿时长

2.2 months

期刊介绍： Science China Chemistry, co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China and published by Science China Press, publishes high-quality original research in both basic and applied chemistry. Indexed by Science Citation Index, it is a premier academic journal in the field. Categories of articles include: Highlights. Brief summaries and scholarly comments on recent research achievements in any field of chemistry. Perspectives. Concise reports on thelatest chemistry trends of interest to scientists worldwide, including discussions of research breakthroughs and interpretations of important science and funding policies. Reviews. In-depth summaries of representative results and achievements of the past 5–10 years in selected topics based on or closely related to the research expertise of the authors, providing a thorough assessment of the significance, current status, and future research directions of the field.