类器官在皮肤伤口愈合

IF 6.3 1区医学 Q1 DERMATOLOGY

Burns & Trauma Pub Date : 2025-01-03 DOI:10.1093/burnst/tkae077

Zitong Wang, Feng Zhao, Hongxin Lang, Haiyue Ren, Qiqi Zhang, Xing Huang, Cai He, Chengcheng Xu, Chiyu Tan, Jiajie Ma, Shu Duan, Zhe Wang

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引用次数: 0

摘要

干细胞（SCs）可以自我复制并分化成多个谱系。类器官是由干细胞衍生的三维培养物，可以在体外复制器官的空间结构和生理特征。皮肤类器官能有效模拟皮肤组织的生理结构和功能，在各种体外环境下可靠地恢复皮肤自然生态。皮肤类器官广泛应用于皮肤发育和病理研究，为药物筛选提供了有价值的见解。此外，它们在皮肤再生和组织修复中起着重要作用。本文综述了皮肤类器官的构建及其在创面愈合中的应用，重点介绍了它们的构建过程，包括皮肤附属物的整合，以及在创面愈合研究中的重大进展。

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Organoids in skin wound healing

Stem cells (SCs) can self-replicate and differentiate into multiple lineages. Organoids, 3D cultures derived from SCs, can replicate the spatial structure and physiological characteristics of organs in vitro. Skin organoids can effectively simulate the physiological structure and function of skin tissue, reliably restoring the natural skin ecology in various in vitro environments. Skin organoids have been employed extensively in skin development and pathology research, offering valuable insights for drug screening. Moreover, they play crucial roles in skin regeneration and tissue repair. This in-depth review explores the construction and applications of skin organoids in wound healing, with a focus on their construction process, including skin appendage integration, and significant advancements in wound-healing research.

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来源期刊

Burns & Trauma 医学-皮肤病学

CiteScore

8.40

自引率

9.40%

发文量

186

审稿时长

6 weeks

期刊介绍： The first open access journal in the field of burns and trauma injury in the Asia-Pacific region, Burns & Trauma publishes the latest developments in basic, clinical and translational research in the field. With a special focus on prevention, clinical treatment and basic research, the journal welcomes submissions in various aspects of biomaterials, tissue engineering, stem cells, critical care, immunobiology, skin transplantation, and the prevention and regeneration of burns and trauma injuries. With an expert Editorial Board and a team of dedicated scientific editors, the journal enjoys a large readership and is supported by Southwest Hospital, which covers authors'' article processing charges.