二氧化钛纳米颗粒：伤口愈合应用的有前途的候选人

IF 6.3 1区医学 Q1 DERMATOLOGY

Burns & Trauma Pub Date : 2025-01-03 DOI:10.1093/burnst/tkae069

Hamed Nosrati, Morteza Heydari

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引用次数: 0

摘要

有效的伤口管理和治疗在临床实践中至关重要，但现有的策略往往不能充分解决皮肤伤口愈合的复杂性。组织工程的最新进展引入了创新的方法，特别是通过使用纳米生物材料来增强愈合过程。在此背景下，二氧化钛纳米颗粒（TiO2 NPs）因其优异的生物特性，包括抗氧化、抗炎和抗菌特性而受到关注。此外，这些纳米颗粒可以被修饰以增强其治疗效果。含有TiO2 NPs的支架和敷料在加速伤口愈合和促进组织再生方面已经证明了有希望的结果。本文综述了伤口愈合过程、TiO2 NPs促进伤口愈合的生物学特性、TiO2 NPs的合成方法、含TiO2 NPs的支架和敷料在伤口愈合中的应用、改性TiO2 NPs在伤口愈合中的应用以及TiO2 NPs的潜在毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Titanium dioxide nanoparticles: a promising candidate for wound healing applications

Effective wound management and treatment are crucial in clinical practice, yet existing strategies often fall short in fully addressing the complexities of skin wound healing. Recent advancements in tissue engineering have introduced innovative approaches, particularly through the use of nanobiomaterials, to enhance the healing process. In this context, titanium dioxide nanoparticles (TiO2 NPs) have garnered attention due to their excellent biological properties, including antioxidant, anti-inflammatory, and antimicrobial properties. Furthermore, these nanoparticles can be modified to enhance their therapeutic benefits. Scaffolds and dressings containing TiO2 NPs have demonstrated promising outcomes in accelerating wound healing and enhancing tissue regeneration. This review paper covers the wound healing process, the biological properties of TiO2 NPs that make them suitable for promoting wound healing, methods for synthesizing TiO2 NPs, the use of scaffolds and dressings containing TiO2 NPs in wound healing, the application of modified TiO2 NPs in wound healing, and the potential toxicity of TiO2 NPs.

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来源期刊

Burns & Trauma 医学-皮肤病学

CiteScore

8.40

自引率

9.40%

发文量

186

审稿时长

6 weeks

期刊介绍： The first open access journal in the field of burns and trauma injury in the Asia-Pacific region, Burns & Trauma publishes the latest developments in basic, clinical and translational research in the field. With a special focus on prevention, clinical treatment and basic research, the journal welcomes submissions in various aspects of biomaterials, tissue engineering, stem cells, critical care, immunobiology, skin transplantation, and the prevention and regeneration of burns and trauma injuries. With an expert Editorial Board and a team of dedicated scientific editors, the journal enjoys a large readership and is supported by Southwest Hospital, which covers authors'' article processing charges.