Jiang Wang, Aizhang Zhu, Jie Chen, Rui Zeng, Siyi Wang, Lihuan Chen, Ying Chen, Qianqian Min, Wei Li, Dongmei Ye, Ruohan Wu, Fayi Xie, Tenghui Fan, Ke Zhu, Wan Zhu, Hongmei Hu, Conghua Wang, Xiaoming Zhang
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Longitudinal analyses from 2011 to 2015 indicated that participants in frailty, cognitive impairment, and cognitive frailty had multivariable-adjusted ORs of 1.28 (95% CI 1.05-1.58; P = 0.0165), 1.39 (95% CI 1.01-1.91; P = 0.0411), and 1.57 (95% CI 1.05-2.35; P = 0.0273), respectively, for new-onset depression relative to no diseased group.</p><p><strong>Limitations: </strong>The definition of depression relied solely on self-reported data.</p><p><strong>Conclusion: </strong>In the middle-aged and elderly Chinese population, patients with cognitive frailty have a higher risk of depression than those with only frailty and cognitive impairment. 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引用次数: 0
摘要
背景：认知脆弱和抑郁症之间的相互作用仍然没有得到充分的了解，缺乏前瞻性队列研究的证据。本研究旨在阐明认知脆弱与事件性抑郁风险之间的关系。方法：利用2011年、2013年和2015年中国健康与退休纵向研究（CHARLS）的数据，根据国际共识小组制定的认知衰弱标准对受试者进行分类。采用多元逻辑回归模型来检验虚弱、认知障碍、认知虚弱和抑郁之间的横断面和纵向关联。进行亚组分析和相互作用试验以确定潜在的效果调节剂。结果：2011年，该研究包括4514名参与者，到2015年随访了2330人。横断面分析显示，被分类为虚弱、认知障碍和认知虚弱的参与者表现出抑郁症的多变量调整优势比（ORs）为1.87 (95% CI 1.60-2.18；P < 0.001), 1.97 (95% ci 1.58-2.47；P < 0.001), 3.38 (95% CI 2.66-4.29；P < 0.001)，与未患病组相比。2011年至2015年的纵向分析表明，虚弱、认知障碍和认知虚弱的参与者的多变量调整后的or为1.28 (95% CI 1.05-1.58；P = 0.0165), 1.39 (95% ci 1.01-1.91；P = 0.0411), 1.57 (95% CI 1.05-2.35；P = 0.0273)。局限性：抑郁症的定义完全依赖于自我报告的数据。结论：在中国中老年人群中，有认知衰弱的患者发生抑郁症的风险高于仅有虚弱和认知障碍的患者。这可能提示卫生保健提供者应该更多地关注那些认知衰弱患者的心理健康。
Association Between Cognitive Frailty and Depression: A Prospective Cohort Study of Adults Aged 45 Years and Older in China.
Background: The interplay between cognitive frailty and depression remains inadequately understood, with a paucity of evidence from prospective cohort studies. Our study aims to elucidate the relationship between cognitive frailty and the risk of incident depression.
Methods: Utilizing data from the China Health and Retirement Longitudinal Study (CHARLS) spanning 2011, 2013, and 2015, subjects were classified according to cognitive frailty criteria established by an international consensus panel. Multiple logistic regression models were employed to examine the cross-sectional and longitudinal associations between frailty, cognitive impairment, cognitive frailty, and depression. Subgroup analyses and interaction tests were conducted to identify potential effect modifiers.
Results: In 2011, the study encompassed 4514 participants, with 2330 individuals followed up through 2015. Cross-sectional analyses revealed that participants classified in frailty, cognitive impairment, and cognitive frailty exhibited multivariable-adjusted odds ratios (ORs) for depression of 1.87 (95% CI 1.60-2.18; P < 0.001), 1.97 (95% CI 1.58-2.47; P < 0.001), and 3.38 (95% CI 2.66-4.29; P < 0.001), respectively, compared to no diseased group. Longitudinal analyses from 2011 to 2015 indicated that participants in frailty, cognitive impairment, and cognitive frailty had multivariable-adjusted ORs of 1.28 (95% CI 1.05-1.58; P = 0.0165), 1.39 (95% CI 1.01-1.91; P = 0.0411), and 1.57 (95% CI 1.05-2.35; P = 0.0273), respectively, for new-onset depression relative to no diseased group.
Limitations: The definition of depression relied solely on self-reported data.
Conclusion: In the middle-aged and elderly Chinese population, patients with cognitive frailty have a higher risk of depression than those with only frailty and cognitive impairment. This may suggest that health care providers should pay more attention to the mental health of those patients with cognitive frailty.
期刊介绍：
Clinical Interventions in Aging, is an online, peer reviewed, open access journal focusing on concise rapid reporting of original research and reviews in aging. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes that result from maladaptive changes in the body associated with aging. This journal is directed at a wide array of scientists, engineers, pharmacists, pharmacologists and clinical specialists wishing to maintain an up to date knowledge of this exciting and emerging field.
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