[派姆单抗联合卡铂和培美曲塞治疗后致命性肝炎]。

Q4 Medicine

Ugeskrift for laeger Pub Date : 2024-12-16 DOI:10.61409/V06240442

Rasmus Strøm Risbjerg, Niels Kristian Aagaard, Lisbet Grønbæk, Signe Hertz Hansen, Katja Maretty Kongstad, Konstantin Kazankov

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引用次数: 0

摘要

免疫治疗引起的肝炎是免疫检查点抑制剂的一种众所周知且相对常见的副作用。它通常是轻度到中度，对皮质类固醇反应良好，完全恢复。然而，在极少数情况下，严重的肝损伤可能会发展，导致暴发性肝衰竭。在这个病例报告中，我们报告了一个急性暴发性肝衰竭的病例，尽管有充分的治疗，67岁男性在卡铂、培美曲塞和派姆单抗联合治疗转移性肺癌后仍有致命的结果。

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[Fatal hepatitis after pembrolizumab in combination therapy with carboplatin and pemetrexed].

Immunotherapy-induced hepatitis is a well-known and relatively common side effect of immune checkpoint inhibitors. It is usually mild to moderate and responds well to corticosteroids with a full recovery. However, in rare cases, severe liver injury may develop, leading to fulminant liver failure. In this case report, we present a case of acute fulminant liver failure with a fatal outcome despite adequate treatment in a 67-year-old male following a combination therapy of carboplatin, pemetrexed, and pembrolizumab for metastatic lung cancer.

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来源期刊

Ugeskrift for laeger Medicine-Medicine (all)

CiteScore

0.20

自引率

0.00%

发文量

345

期刊介绍： The Ulster Medical Journal is an international general medical journal with contributions on all areas of medical and surgical specialties relevant to a general medical readership. It retains a focus on material relevant to the health of the Northern Ireland population. The Honorary Editor would welcome offers of papers for publication. Prospective authors are invited to read the notice to contributors.