广泛性焦虑障碍(GAD)患者决策过程中风险和奖励加工的神经调节。

IF 3.9 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Vahid Nejati, Jamal Amani Rad, Amir Hosein Hadian Rasanan
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引用次数: 0

摘要

广泛性焦虑障碍(GAD)患者的未来导向加工受损,奖励感知改变,这可能涉及腹内侧前额叶皮层(vmPFC)和背外侧前额叶皮层(dlPFC)。29名成人广泛性焦虑症患者在不同刺激条件下接受5次经颅直流电刺激(tDCS),并完成气球模拟冒险任务(BART)和延迟贴现任务(DDT)。刺激条件为:正极dlPFC (F3)/正极vmPFC (Fp2)、正极vmPFC (Fp2)/正极dlPFC (F3)、正极dlPFC (F3)/正极右肩、正极vmPFC (Fp2)/正极左肩、假刺激。认知建模用于提取基于过程的度量。基于过程的建模措施,而不是传统的基于结果的措施,显示了增产条件的显著影响。所有真实刺激条件都提高了BART的患病率更新率和风险承担率。此外,对于阳极dlPFC (F3)/阴极vmPFC (Fp2)、阳极vmPFC (Fp2)/阴极dlPFC (F3)以及阳极vmPFC (Fp2)/阴极左肩刺激,我们观察到对爆炸的先验信念有所改善。此外,对于阳极dlPFC (F3)/阴极vmPFC (Fp2),阳极dlPFC (F3)/阴极右肩,阳极vmPFC (Fp2)/阴极左肩,我们观察到更稳定的选择模式。颅外返回电极刺激dlPFC和vmPFC时,滴滴涕、指数折现率和随机性均有改善。根据特定电极位置产生的显著性能差异,讨论了目标区域的不同作用。结果表明,vmPFC和dlPFC控制着不同的奖励处理领域。vmPFC与基于价值的积极期望和基于机会的随机性决策更相关,而dlPFC与基于逻辑的决策更相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Neuromodulation of risk and reward processing during decision making in individuals with general anxiety disorder (GAD).

Neuromodulation of risk and reward processing during decision making in individuals with general anxiety disorder (GAD).

Neuromodulation of risk and reward processing during decision making in individuals with general anxiety disorder (GAD).

Individuals with general anxiety disorder (GAD) have an impaired future-oriented processing and altered reward perception, which might involve the ventromedial prefrontal cortex (vmPFC) and dorsolateral prefrontal cortex (dlPFC). Twenty-nine adults with GAD performed the balloon analogue risk-taking task (BART) and delay discounting task (DDT) during five sessions of transcranial direct current stimulation (tDCS) with different stimulation conditions. The stimulation conditions were: anodal dlPFC (F3)/cathodal vmPFC (Fp2), anodal vmPFC (Fp2)/cathodal dlPFC (F3), anodal dlPFC (F3)/cathodal right shoulder, anodal vmPFC (Fp2)/cathodal left shoulder, and sham stimulation. Cognitive modeling was used to extract process-based measures. The process-based modeling measures, rather than conventional outcome-based measures, showed a significant effect of stimulation condition. All real stimulation conditions improved the updating rate of prevalence, and risk taking in the BART. Moreover, for anodal dlPFC (F3)/cathodal vmPFC (Fp2), anodal vmPFC (Fp2)/cathodal dlPFC (F3), and anodal vmPFC (Fp2)/cathodal left shoulder stimulations we have observed an improvement in prior beliefs about the explosion. Also, for anodal dlPFC (F3)/cathodal vmPFC (Fp2), anodal dlPFC (F3)/cathodal right shoulder, anodal vmPFC (Fp2)/cathodal left shoulder we have observed more stable choice pattern. the DDT, exponential discounting rate and randomness were improved during anodal dlPFC and anodal vmPFC stimulation with extracranial return electrodes. Different roles of the targeted areas are discussed based on significant performance differences resulting from the specific electrode positions. The results suggest that different domains of reward processing are controlled by the vmPFC and dlPFC. The vmPFC is more relevant for value-based decision making with a positive expectation and chance-based randomness, whereas the dlPFC is more relevant for logic-based decision making.

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来源期刊
Scientific Reports
Scientific Reports Natural Science Disciplines-
CiteScore
7.50
自引率
4.30%
发文量
19567
审稿时长
3.9 months
期刊介绍: We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections. Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021). •Engineering Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live. •Physical sciences Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics. •Earth and environmental sciences Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems. •Biological sciences Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants. •Health sciences The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.
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