增加细胞培养实践的生物分子相关性。

IF 9 2区医学 Q1 CELL BIOLOGY

Journal of Biomedical Science Pub Date : 2025-01-03 DOI:10.1186/s12929-024-01095-6

Raluca E Ghebosu, Lawrence Hui, Joy Wolfram

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引用次数: 0

摘要

培养基补充剂的生物分子相关性是影响细胞培养实践的一个关键挑战。常用补充剂的生物分子组成与生理环境不同，影响体外研究结论的有效性。本文讨论了常用补充剂的优缺点，包括根据具体情况选择补充剂以提高生物分子相关性的考虑因素，特别是在纳米医学和细胞外囊研究中。

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Increasing the biomolecular relevance of cell culture practice.

The biomolecular relevance of medium supplements is a key challenge affecting cell culture practice. The biomolecular composition of commonly used supplements differs from that of a physiological environment, affecting the validity of conclusions drawn from in vitro studies. This article discusses the advantages and disadvantages of common supplements, including context-dependent considerations for supplement selection to improve biomolecular relevance, especially in nanomedicine and extracellular vesicle research.

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来源期刊

Journal of Biomedical Science 医学-医学：研究与实验

CiteScore

18.50

自引率

0.90%

发文量

审稿时长

1 months

期刊介绍： The Journal of Biomedical Science is an open access, peer-reviewed journal that focuses on fundamental and molecular aspects of basic medical sciences. It emphasizes molecular studies of biomedical problems and mechanisms. The National Science and Technology Council (NSTC), Taiwan supports the journal and covers the publication costs for accepted articles. The journal aims to provide an international platform for interdisciplinary discussions and contribute to the advancement of medicine. It benefits both readers and authors by accelerating the dissemination of research information and providing maximum access to scholarly communication. All articles published in the Journal of Biomedical Science are included in various databases such as Biological Abstracts, BIOSIS, CABI, CAS, Citebase, Current contents, DOAJ, Embase, EmBiology, and Global Health, among others.