d -二聚体水平与早期宫颈癌手术后复发的关系

IF 2.5 4区医学 Q2 OBSTETRICS & GYNECOLOGY

International Journal of Women's Health Pub Date : 2024-12-27 eCollection Date: 2024-01-01 DOI:10.2147/IJWH.S481692

Qin Chen, Lele Zang, Qin Xu, Min Wang, Huaqin Lin, Yanyan Liu, Yi Fang

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ORs and 95% CIs were calculated.Results: The end of follow-up was when CC recurred or 3 years after surgery. In sum, 80 patients suffered CC recurrence, accounting for 9% of all participants. The risk of recurrence was elevated in CC patients from the elevated group (EG), with an adjusted OR of 2.16 (95% CI 1.28-3.62). The risk of recurrence was increased in the EG in patients with cervical squamous cell carcinoma undergoing surgery in the adjusted model (OR 3.58, 95% CI 1.02-12.89). 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引用次数: 0

摘要

目的：分析早期宫颈癌（CC）患者手术后血浆d -二聚体水平与复发风险的关系。方法：本队列研究选取2016年6月至2019年12月在福建省肿瘤医院接受手术治疗的早期CC患者888例。采用单因素logistic回归筛选影响早期CC手术后复发的混杂因素。与手术治疗后早期CC复发显著相关的变量是混杂因素。建立单因素和多因素logistic回归模型，探讨d -二聚体水平与早期CC手术后复发风险之间的关系。计算or和95% ci。结果：随访结束于CC复发或术后3年。总共有80例患者出现CC复发，占所有参与者的9%。升高组（EG） CC患者的复发风险升高，调整后OR为2.16 （95% CI 1.28-3.62）。在调整后的模型中，宫颈鳞状细胞癌手术患者EG复发的风险增加（OR 3.58, 95% CI 1.02-12.89）。对于宫颈腺癌患者，EG患者的复发风险增加（OR 1.87, 95% CI 1.01-3.48）。结论：高水平的d -二聚体与手术治疗早期CC患者复发风险增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Association Between D-Dimer Levels and Recurrence in Patients with Early-Stage Cervical Cancer after Surgical Treatment.

Purpose: This study was conducted to analyze the relationship between plasma D-dimer levels and the risk of recurrence after surgical treatment in patients with early-stage cervical cancer (CC).

Methods: In this cohort study, 888 participants with early-stage CC undergoing surgical treatment in Fujian Cancer Hospital between June 2016 and December 2019 were identified. Univariate logistic regression was used to screen confounding factors affecting the recurrence of early CC after surgical treatment. Variables significantly associated with the recurrence of early CC after surgical treatment were confounding factors. Univariate and multivariate logistic regression models were established to explore the association between D-dimer levels and the risk of recurrence of early CC after surgical treatment. ORs and 95% CIs were calculated.

Results: The end of follow-up was when CC recurred or 3 years after surgery. In sum, 80 patients suffered CC recurrence, accounting for 9% of all participants. The risk of recurrence was elevated in CC patients from the elevated group (EG), with an adjusted OR of 2.16 (95% CI 1.28-3.62). The risk of recurrence was increased in the EG in patients with cervical squamous cell carcinoma undergoing surgery in the adjusted model (OR 3.58, 95% CI 1.02-12.89). As for cervical adenocarcinoma patients, the increased risk of recurrence was identified in patients from the EG (OR 1.87, 95% CI 1.01-3.48).

Conclusion: High levels of D-dimer were associated with increased recurrence risk of CC in patients at the early stage of surgical treatment.

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来源期刊

International Journal of Women's Health OBSTETRICS & GYNECOLOGY-

CiteScore

3.70

自引率

0.00%

发文量

194

审稿时长

16 weeks

期刊介绍： International Journal of Women''s Health is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of women''s healthcare including gynecology, obstetrics, and breast cancer. Subject areas include: Chronic conditions including cancers of various organs specific and not specific to women Migraine, headaches, arthritis, osteoporosis Endocrine and autoimmune syndromes - asthma, multiple sclerosis, lupus, diabetes Sexual and reproductive health including fertility patterns and emerging technologies to address infertility Infectious disease with chronic sequelae including HIV/AIDS, HPV, PID, and other STDs Psychological and psychosocial conditions - depression across the life span, substance abuse, domestic violence Health maintenance among aging females - factors affecting the quality of life including physical, social and mental issues Avenues for health promotion and disease prevention across the life span Male vs female incidence comparisons for conditions that affect both genders.