膜联蛋白A1：缺血性卒中的前兆（综述）。

IF 3.4 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Molecular medicine reports Pub Date : 2025-03-01 Epub Date: 2025-01-03 DOI:10.3892/mmr.2024.13427

Chen Tang, Rui Lan, Dong-Rui Ma, Min Zhao, Yong Zhang, Hong-Yu Li, Shuang Liu, Bo-Yang Li, Jie-Li Yang, Hui-Jie Yang, Zhen-Qiang Zhang

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引用次数: 0

摘要

缺血性脑卒中是一种常见的临床疾病，对全球构成了重大挑战。制定解决这一问题的创新战略至关重要。膜联蛋白A1 （ANXA1）是膜联蛋白超家族的关键成员，具有抑制炎症因子释放、促进吞噬、阻断白细胞迁移等多种功能。有证据表明，ANXA1在缺血性脑卒中的发病机制中起关键作用。本文综述了ANXA1在抗动脉粥样硬化、炎症过程、血脑屏障保护、血小板聚集和抗凋亡机制中的作用。探讨了ANXA1在缺血性脑卒中治疗中的潜在应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Annexin A1: The dawn of ischemic stroke (Review).

Ischemic stroke is a prevalent clinical condition that poses a significant global challenge. Developing innovative strategies to address this issue is crucial. Annexin A1 (ANXA1), a key member of the annexin superfamily, performs various functions, such as inhibiting inflammatory factor release, promoting phagocytosis, and blocking leukocyte migration. Evidence indicates that ANXA1 plays a pivotal role in the pathogenesis of ischemic stroke. The present article reviews involvement of ANXA1 in anti‑atherosclerosis, inflammatory processes, blood‑brain barrier protection, platelet aggregation and anti‑apoptotic mechanisms. The potential applications of ANXA1 in treating ischemic stroke are also explored.

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来源期刊

Molecular medicine reports 医学-病理学

CiteScore

7.60

自引率

0.00%

发文量

321

审稿时长

1.5 months

期刊介绍： Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.