{"title":"Association Between Average Daily Activity Counts and Knee Osteoarthritis Progression.","authors":"Xiaozhen Tang, Dongze Li, Haishan Yao, Xuanchen Chen, Liangquan Fan, Zhenhai Hou","doi":"10.1097/PHM.0000000000002697","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To explore the relationship between daily activity counts and knee osteoarthritis (OA) progression.</p><p><strong>Design: </strong>A cohort study using Osteoarthritis Initiative (OAI) data included 610 participants aged 45-79 years with knee OA or at risk. Daily activity counts were measured using ActiGraph GT1M accelerometers. OA progression was assessed via Kellgren-Lawrence (KL) grade and joint space narrowing (JSN) scores over two years. Cox proportional hazard and Restricted Cubic Spline models identified the dose-response relationship and optimal activity threshold.</p><p><strong>Results: </strong>The average age of participants was 63.7 years, with 44.8% male. A U-shaped relationship was observed between daily activity counts and OA progression. Moderate activity levels could be associated with a reduced risk of KL-grade (adjusted HR: 0.33; 95% CI: 0.24-0.44) and JSN-score progression (HR: 0.31; 95% CI: 0.25-0.38) for activity below 3263.3 counts/min. However, higher activity levels may increase KL-grade (HR: 1.57; 95% CI: 1.40-2.75) and JSN-score progression risk (HR: 1.27; 95% CI: 1.13-1.43).</p><p><strong>Conclusion: </strong>Moderate activity may protect against knee OA progression, while low and high levels may increase risk. Tailored activity recommendations are needed for individuals with or at risk for OA. Future research should investigate the mechanisms and refine activity thresholds for OA management.</p>","PeriodicalId":7850,"journal":{"name":"American Journal of Physical Medicine & Rehabilitation","volume":" ","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Physical Medicine & Rehabilitation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/PHM.0000000000002697","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"REHABILITATION","Score":null,"Total":0}
引用次数: 0
摘要
目的：探讨每日活动次数与膝关节骨性关节炎（OA）进展之间的关系：探讨日常活动次数与膝关节骨性关节炎（OA）进展之间的关系：设计：一项使用骨关节炎倡议（OAI）数据进行的队列研究纳入了610名年龄在45-79岁之间的膝关节OA患者或高危患者。使用ActiGraph GT1M加速度计测量每日活动量。通过两年内凯尔格伦-劳伦斯（Kellgren-Lawrence，KL）分级和关节间隙狭窄（JSN）评分来评估 OA 进展情况。Cox 比例危险模型和受限立方样条模型确定了剂量-反应关系和最佳活动阈值：结果：参与者的平均年龄为 63.7 岁，男性占 44.8%。每日活动量与 OA 进展之间呈 U 型关系。活动量低于 3263.3 次/分钟时，适度活动可降低 KL 等级（调整后 HR：0.33；95% CI：0.24-0.44）和 JSN 评分进展（HR：0.31；95% CI：0.25-0.38）的风险。然而，较高的活动量可能会增加KL等级（HR：1.57；95% CI：1.40-2.75）和JSN-score进展风险（HR：1.27；95% CI：1.13-1.43）：结论：适度的活动可以预防膝关节 OA 的恶化，而低水平和高水平的活动可能会增加风险。需要为患有或有 OA 风险的人提供有针对性的活动建议。未来的研究应探究其机制，并完善活动量阈值，以便进行 OA 管理。
Association Between Average Daily Activity Counts and Knee Osteoarthritis Progression.
Objective: To explore the relationship between daily activity counts and knee osteoarthritis (OA) progression.
Design: A cohort study using Osteoarthritis Initiative (OAI) data included 610 participants aged 45-79 years with knee OA or at risk. Daily activity counts were measured using ActiGraph GT1M accelerometers. OA progression was assessed via Kellgren-Lawrence (KL) grade and joint space narrowing (JSN) scores over two years. Cox proportional hazard and Restricted Cubic Spline models identified the dose-response relationship and optimal activity threshold.
Results: The average age of participants was 63.7 years, with 44.8% male. A U-shaped relationship was observed between daily activity counts and OA progression. Moderate activity levels could be associated with a reduced risk of KL-grade (adjusted HR: 0.33; 95% CI: 0.24-0.44) and JSN-score progression (HR: 0.31; 95% CI: 0.25-0.38) for activity below 3263.3 counts/min. However, higher activity levels may increase KL-grade (HR: 1.57; 95% CI: 1.40-2.75) and JSN-score progression risk (HR: 1.27; 95% CI: 1.13-1.43).
Conclusion: Moderate activity may protect against knee OA progression, while low and high levels may increase risk. Tailored activity recommendations are needed for individuals with or at risk for OA. Future research should investigate the mechanisms and refine activity thresholds for OA management.
期刊介绍：
American Journal of Physical Medicine & Rehabilitation focuses on the practice, research and educational aspects of physical medicine and rehabilitation. Monthly issues keep physiatrists up-to-date on the optimal functional restoration of patients with disabilities, physical treatment of neuromuscular impairments, the development of new rehabilitative technologies, and the use of electrodiagnostic studies. The Journal publishes cutting-edge basic and clinical research, clinical case reports and in-depth topical reviews of interest to rehabilitation professionals.
Topics include prevention, diagnosis, treatment, and rehabilitation of musculoskeletal conditions, brain injury, spinal cord injury, cardiopulmonary disease, trauma, acute and chronic pain, amputation, prosthetics and orthotics, mobility, gait, and pediatrics as well as areas related to education and administration. Other important areas of interest include cancer rehabilitation, aging, and exercise. The Journal has recently published a series of articles on the topic of outcomes research. This well-established journal is the official scholarly publication of the Association of Academic Physiatrists (AAP).
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