Youngkook Kim, So Yeon Jun, Jeehae Oh, Jaeun Koo, Eunji Lee
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Multiple linear regression was used to evaluate the associations between ipsilesional motor performance and the microstructural integrity of relevant white matter tracts (Biomarker models) and cognitive function test scores (Cognition models).</p><p><strong>Results: </strong>Biomarker models, including the genu of the corpus callosum, ipsilesional cingulum, fornix, uncinate fasciculus, superior longitudinal fasciculus, and contralesional inferior longitudinal fasciculus, showed a significant association with ipsilesional motor performance. Cognition models, including Mini-Mental State Examination and Trail Making Test-B, were significantly associated with ipsilesional motor performance. Final regression models (combined Cognition and Biomarker models) revealed that the performance time of Trail Making Test-B, in combination with biomarkers, including the genu of the corpus callosum, ipsilesional superior longitudinal fasciculus, and ipsilesional cingulum, predicted ipsilesional motor performance with high explanatory power (<i>adjusted R</i><sup>2</sup> = .721, .709, and .696, respectively).</p><p><strong>Conclusions: </strong>This study demonstrated that executive function is associated with poststroke ipsilesional motor performance, as evidenced by the microstructural biomarkers involved in executive function. 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引用次数: 0
摘要
背景：单侧半脑卒中可损害同侧运动功能，这对于卒中后获得最佳功能预后至关重要。然而，导致同伤性运动表现障碍的具体大脑结构仍不清楚。目的：探讨同患性运动表现与相关神经通路微观结构完整性的关系。方法：本研究纳入60例中风早期亚急性期恢复的连续患者。采用盒块法评估裸眼运动性能。采用多元线性回归评估同侧运动表现与相关白质束微结构完整性（生物标志物模型）和认知功能测试分数（认知模型）之间的关系。结果：生物标志物模型，包括胼胝体、同侧扣带、穹窿、钩侧束、上纵束和对侧下纵束，显示了与同侧运动表现的显著关联。认知模型，包括迷你精神状态测试和轨迹测试- b，与同侧运动表现显著相关。最终的回归模型（联合认知和生物标志物模型）显示，Trail Making Test-B的表现时间与胼胝体膝、同侧上纵束和同侧扣带等生物标志物联合预测同侧运动表现具有较高的解释力（调整后R2 =）。分别为。721、。709和。696)。结论：本研究表明，执行功能与脑卒中后同侧运动表现相关，与执行功能相关的微结构生物标志物证明了这一点。我们的研究结果强调，认知功能的综合作用而不是运动系统与中风后的同侧运动表现密切相关。
Poststroke Ipsilesional Motor Performance: Microstructural Biomarkers and Their Associations With Executive Function.
Background: Unilateral hemispheric stroke can impair the ipsilesional motor performance, which is crucial for attaining optimal functional outcomes poststroke. However, the specific brain structures contributing to ipsilesional motor performance impairment remain unclear.
Objective: To explore the link between ipsilesional motor performance and the microstructural integrity of relevant neural pathways.
Methods: This study enrolled 60 consecutive patients in the early subacute phase of stroke recovery. Ipsilesional motor performance was assessed using the Box and Block Test. Multiple linear regression was used to evaluate the associations between ipsilesional motor performance and the microstructural integrity of relevant white matter tracts (Biomarker models) and cognitive function test scores (Cognition models).
Results: Biomarker models, including the genu of the corpus callosum, ipsilesional cingulum, fornix, uncinate fasciculus, superior longitudinal fasciculus, and contralesional inferior longitudinal fasciculus, showed a significant association with ipsilesional motor performance. Cognition models, including Mini-Mental State Examination and Trail Making Test-B, were significantly associated with ipsilesional motor performance. Final regression models (combined Cognition and Biomarker models) revealed that the performance time of Trail Making Test-B, in combination with biomarkers, including the genu of the corpus callosum, ipsilesional superior longitudinal fasciculus, and ipsilesional cingulum, predicted ipsilesional motor performance with high explanatory power (adjusted R2 = .721, .709, and .696, respectively).
Conclusions: This study demonstrated that executive function is associated with poststroke ipsilesional motor performance, as evidenced by the microstructural biomarkers involved in executive function. Our findings highlight that the comprehensive role of cognitive functioning rather than the motor system is closely linked to poststroke ipsilesional motor performance.
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