美国现役特种作战部队灰质-白质界面的神经炎症。

IF 1.8 Q3 CLINICAL NEUROLOGY
Neurotrauma reports Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI:10.1089/neur.2024.0116
Brian L Edlow, Chieh-En J Tseng, Natalie Gilmore, Isabella R McKinney, Samantha L Tromly, Katryna B Deary, Collin G Hu, Brian C Healy, David S Priemer, Christine L Mac Donald, Kristen Dams-O'Connor, Douglas N Greve, Yelena G Bodien, Daniel P Perl, Jacob M Hooker, Nicole R Zürcher
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引用次数: 0

摘要

来自尸检研究的新证据表明,灰质交界处的界面星形胶质瘢痕(IAS)是军事人员反复爆炸脑损伤的病理特征。然而,目前还没有能够检测到IAS的体内神经影像学测试,这是诊断、预防和治疗的主要障碍。在27名高水平累积爆炸暴露的现役美国特种作战部队人员中,我们使用[11C]PBR28进行了转运蛋白(TSPO)正电子发射断层扫描(PET),以检测皮层灰质界面的神经炎症,这是尸检研究中报道的IAS的神经解剖学位置。将个体操作员的TSPO信号与9名健康平民志愿者组成的对照组的平均TSPO信号进行比较。我们发现5名操作员(18.5%)在皮层灰质-白质界面处有TSPO信号,比对照平均值高出2个标准差以上。用广义爆炸暴露值测量的累积爆炸暴露在5名TSPO信号升高的操作员和22名TSPO信号未升高的操作员之间没有差异。虽然神经炎症和IAS之间的病理生理联系尚不确定,但这些初步观察结果为进一步研究TSPO PET作为重复性爆炸脑损伤的潜在生物标志物提供了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neuroinflammation at the Gray-White Matter Interface in Active-Duty U.S. Special Operations Forces.

Emerging evidence from autopsy studies indicates that interface astroglial scarring (IAS) at the gray-white matter junction is a pathological signature of repeated blast brain injury in military personnel. However, there is currently no in vivo neuroimaging test that detects IAS, which is a major barrier to diagnosis, prevention, and treatment. In 27 active-duty U.S. Special Operations Forces personnel with high levels of cumulative blast exposure, we performed translocator protein (TSPO) positron emission tomography (PET) using [11C]PBR28 to detect neuroinflammation at the cortical gray-white matter interface, a neuroanatomic location where IAS has been reported in autopsy studies. TSPO signal in individual Operators was compared with the mean TSPO signal in a control group of nine healthy civilian volunteers. We identified five Operators (18.5%) with TSPO signal at the cortical gray-white matter interface that was more than 2 standard deviations above the control mean. Cumulative blast exposure, as measured by the generalized blast exposure value, did not differ between the five Operators with elevated TSPO signal and the 22 Operators without elevated TSPO signal. While the pathophysiologic link between neuroinflammation and IAS remains uncertain, these preliminary observations provide the basis for further investigation into TSPO PET as a potential biomarker of repeated blast brain injury.

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来源期刊
CiteScore
2.40
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0.00%
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