[单细胞牙齿发育时空图谱：进展与展望]。

Q4 Medicine

中华口腔医学杂志 Pub Date : 2025-01-09 DOI:10.3760/cma.j.cn112144-20241010-00377

X C Li, X S Wu

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引用次数: 0

摘要

单细胞和空间多组学技术能够同时分析数千个不同状态的细胞，揭示它们的转录谱、染色质可及性和空间定位。单细胞多组学在牙齿发育过程中不同细胞亚型的定义、功能、进化和相互作用等方面取得了重大进展。我们总结了最近牙齿发育单细胞多组学研究的主要发现，强调了它们对该领域的贡献，并讨论了牙齿发育基因组学研究的未来前景。

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[Single-cell spatiotemporal atlas of tooth development: progress and prospects].

Single-cell and spatial multi-omics technologies enable the simultaneous analysis of thousands of cells in various states, revealing their transcriptional profiles, chromatin accessibility, and spatial positioning. Recent advances in single-cell multi-omics have led to significant discoveries regarding the definition, function, evolution, and interaction of various cell subtypes during tooth development. We summarize key findings from recent single-cell multi-omics studies on tooth development, highlighting their contributions to the field and discussing future perspectives in dental developmental genomics research.

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来源期刊

中华口腔医学杂志 Medicine-Medicine (all)

CiteScore

0.90

自引率

0.00%

发文量

9692

期刊介绍： Founded in August 1953, Chinese Journal of Stomatology is a monthly academic journal of stomatology published publicly at home and abroad, sponsored by the Chinese Medical Association and co-sponsored by the Chinese Stomatology Association. It mainly reports the leading scientific research results and clinical diagnosis and treatment experience in the field of oral medicine, as well as the basic theoretical research that has a guiding role in oral clinical practice and is closely combined with oral clinical practice. Chinese Journal of Over the years, Stomatology has been published in Medline, Scopus database, Toxicology Abstracts Database, Chemical Abstracts Database, American Cancer database, Russian Abstracts database, China Core Journal of Science and Technology, Peking University Core Journal, CSCD and other more than 20 important journals at home and abroad Physical medicine database and retrieval system included.