玻利维亚松鼠猴(Saimiri boliviensis boliviensisv)使用单克隆抗体选择性消耗淋巴细胞群时的病毒蛋白特异性免疫反应。

IF 1.5 4区 医学 Q4 IMMUNOLOGY
Viral immunology Pub Date : 2025-01-01 Epub Date: 2025-01-02 DOI:10.1089/vim.2024.0080
Pramod N Nehete, Bharti P Nehete, Sriram Chitta
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引用次数: 0

摘要

在器官移植受者和肿瘤、神经和自身免疫性疾病患者的治疗中越来越多地使用免疫抑制性单克隆抗体,可能导致在人类中持续存在的病毒因子的再激活导致严重的发病率和死亡率。松鼠猴多瘤病毒是在玻利维亚松鼠猴(SQM)中自然发现的,可能是研究多瘤病毒相关发病机制和实验性治疗和预防策略的有用模型。给两组不同的松鼠猴,单剂量的抗B细胞抗体(利妥昔单抗)导致B细胞(CD20+)的完全消耗,而抗CD8单克隆抗体(7pt - 3f9)导致CD8+淋巴细胞的短暂消耗,与对照动物(没有输注任何单克隆抗体的组)相比。这些动物在临床上保持健康,没有病理症状表明免疫抑制的强度和/或持续时间不足以引发潜伏的多瘤和疱疹病毒的致病性再激活。我们观察到,在CD8和CD20缺失组中,循环血浆细胞因子、IL-2、IFN-γ和IL-12的短暂减少降低了JC和BK病毒蛋白特异性增殖反应。本研究清楚地阐明了在人类恶性肿瘤治疗和移植过程中使用耗竭单克隆抗体的免疫抑制方式的后果,并且SQM作为一个很好的模型,在选择潜伏病毒激活最低的剂量时,没有病理后果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Virus Protein-Specific Immune Responses in Selective Depletion of Lymphocyte Populations Using Monoclonal Antibodies in Bolivian Squirrel Monkeys (Saimiri boliviensis boliviensisv).

The increasing use of immune suppressive monoclonal antibodies in the treatment of organ transplant recipients and patients with oncologic, neurological, and autoimmune diseases can lead to serious morbidity and mortality from the reactivation of viral agents that persist in humans. The squirrel monkey polyomaviruses are naturally found in Bolivian squirrel monkeys (SQM) and may be a useful model for the study of polyomavirus-associated pathogenesis and experimental treatment and prevention strategies. Two diverse groups of squirrel monkeys were given, a single dose of an anti-B cell antibody (rituximab) resulting in complete depletion of B cells (CD20+), while an anti-CD8 monoclonal antibody (7 pt-3F9) resulted in a transient depletion of CD8+ lymphocytes compared with control animals (group with no infusion with either of the monoclonal antibodies). The animals remained clinically healthy, with no pathological symptoms suggesting that the intensity and/or duration of immune suppression were inadequate to trigger pathogenic reactivation of the latent polyoma and herpes viruses. We observed a transient reduction in circulating plasma cytokines, IL-2, IFN-γ, and IL-12 reduced JC and BK viral protein-specific proliferative responses in both the CD8 and CD20 depletion groups. This study clearly elucidates the consequences of the use of depletion monoclonal antibodies in immune suppression modalities in the treatment of human malignancies and during transplantation, and SQM acts as a good model in the selection of dosage at which activation of latent viruses is at a minimum, with no pathological consequences.

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来源期刊
Viral immunology
Viral immunology 医学-病毒学
CiteScore
3.60
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Viral Immunology delivers cutting-edge peer-reviewed research on rare, emerging, and under-studied viruses, with special focus on analyzing mutual relationships between external viruses and internal immunity. Original research, reviews, and commentaries on relevant viruses are presented in clinical, translational, and basic science articles for researchers in multiple disciplines. Viral Immunology coverage includes: Human and animal viral immunology Research and development of viral vaccines, including field trials Immunological characterization of viral components Virus-based immunological diseases, including autoimmune syndromes Pathogenic mechanisms Viral diagnostics Tumor and cancer immunology with virus as the primary factor Viral immunology methods.
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