儿童颈动脉内膜-中膜厚度增高与睡眠时间状态的变化：一项前瞻性队列研究。

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY

Sleep medicine Pub Date : 2025-02-01 DOI:10.1016/j.sleep.2024.12.036

Yuxiao Zhu , Chongran Ma , Yanan Qiao , Min Zhao , Miaobing Zheng , Lili Yang , Bo Xi

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引用次数: 0

摘要

背景：短睡眠时间在儿科人群中很常见，并且与颈动脉内膜-中膜厚度（cIMT）升高的风险相关，cIMT是亚临床动脉粥样硬化的标志。然而，随着时间的推移，睡眠持续时间的变化是否会改变儿童高cIMT的风险，我们知之甚少。目的：在一项中国儿童队列研究中，探讨睡眠持续时间状态变化与高cIMT之间的关系。方法：在环台儿童心血管健康队列研究中，于2017年入组1115名6-11岁儿童，并于2021年进行随访。根据儿童在基线和随访时的睡眠持续时间状态（短与正常），将儿童分为四组：持续正常睡眠时间、突发短睡眠时间、解决短睡眠时间和持续短睡眠时间。高cIMT被定义为cIMT水平≥该人群年龄和性别特异性的第90百分位值。结果：与保持正常睡眠时间的儿童相比，突发睡眠时间短（优势比[OR]: 1.71, 95%可信区间[CI]: 1.05-2.77）或持续睡眠时间短（OR: 4.07, 95% CI: 2.10-7.89）的儿童在随访时发生高cIMT的风险显著增加。相反，基线时睡眠时间短但随访时睡眠时间正常的儿童没有增加高cIMT的风险（OR: 1.08, 95% CI: 0.47-2.49）。结论：短睡眠时间的发展或持续与儿童高cIMT风险增加有关，而短睡眠时间的解决可能会降低这种风险。这些发现强调了预防和管理短睡眠时间对促进儿童心血管健康的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Changes in sleep duration status and risk of high carotid intima-media thickness in children: A prospective cohort study

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Changes in sleep duration status and risk of high carotid intima-media thickness in children: A prospective cohort study

Background

Short sleep duration is common in the pediatric population and is associated with an increased risk of high carotid intima-media thickness (cIMT), a marker of subclinical atherosclerosis. However, little is known regarding whether changes in sleep duration status over time can alter the risk of high cIMT in children.

Objectives

To examine the association between changes in sleep duration status and high cIMT in a cohort study of Chinese children.

Methods

A total of 1115 children aged 6–11 years were enrolled in 2017 and then followed up in 2021 in the Huantai Childhood Cardiovascular Health Cohort Study. Children were categorized into four groups based on their sleep duration status (short vs. normal) at baseline and follow-up: persistent normal sleep duration, incident short sleep duration, resolved short sleep duration, and persistent short sleep duration. High cIMT was defined as cIMT levels ≥ age- and sex-specific 90th percentile values of this population.

Results

Compared with children who maintained normal sleep duration, those with incident short sleep duration (odds ratio [OR]: 1.71, 95 % confidence interval [CI]: 1.05–2.77) or persistent short sleep duration (OR: 4.07, 95 % CI: 2.10–7.89) had a significantly increased risk of high cIMT at follow-up. Conversely, children who had short sleep duration at baseline but normal sleep duration at follow-up did not have an increased risk of high cIMT (OR: 1.08, 95 % CI: 0.47–2.49).

Conclusion

The development or persistence of short sleep duration is associated with an increased risk of high cIMT in children, whereas the resolution of short sleep duration may reduce such risk. These findings underscore the importance of preventing and managing short sleep duration to promote cardiovascular health in children.

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来源期刊

Sleep medicine 医学-临床神经学

CiteScore

8.40

自引率

6.20%

发文量

1060

审稿时长

49 days

期刊介绍： Sleep Medicine aims to be a journal no one involved in clinical sleep medicine can do without. A journal primarily focussing on the human aspects of sleep, integrating the various disciplines that are involved in sleep medicine: neurology, clinical neurophysiology, internal medicine (particularly pulmonology and cardiology), psychology, psychiatry, sleep technology, pediatrics, neurosurgery, otorhinolaryngology, and dentistry. The journal publishes the following types of articles: Reviews (also intended as a way to bridge the gap between basic sleep research and clinical relevance); Original Research Articles; Full-length articles; Brief communications; Controversies; Case reports; Letters to the Editor; Journal search and commentaries; Book reviews; Meeting announcements; Listing of relevant organisations plus web sites.