RNA诊断和治疗:综述。

IF 3.6 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
RNA Biology Pub Date : 2025-12-01 Epub Date: 2025-01-03 DOI:10.1080/15476286.2024.2449277
Adeela Fathima Saju, Aditi Mukundan, Divyashree Ms, Raghu Chandrashekhar, Archana Mahadev Rao
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引用次数: 0

摘要

由于RNA优于DNA的优势,以RNA为重点的治疗和诊断一直在分子生物学领域掀起波澜;例如,RNA靶向细胞中几乎任何遗传成分的能力是治疗疾病的一大步。此外,基于rna的疾病诊断正变得越来越流行,特别是在2019冠状病毒病大流行之后,这对绝大多数人来说都需要具有成本效益和高效的诊断试剂盒。基于rna的技术也几乎没有遗传毒性风险,并且可以有效地靶向细胞的不可药物区域。在过去的几十年里,RNA治疗已经有效地展示了医疗行业的未来,而且它只会得到改善。这篇综述文章提供了在诊断和治疗领域使用基于RNA的方法的不同技术的概述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
RNA diagnostics and therapeutics: a comprehensive review.

RNA-focused therapy and diagnostics have been making waves in molecular biology due to the advantages RNA has over DNA; for instance, the ability of RNA to target nearly any genetic component in the cell is a big step in treating disorders. Moreover, RNA-based diagnosis of diseases is only becoming increasingly popular, especially after the COVID-19 pandemic, which brought up the need for cost-effective and efficient diagnosing kits for the vast majority. RNA-based techniques also have close to no risk of genotoxicity and can efficiently target undruggable regions of the cell. RNA treatments have effectively shown the future of the medical industry in the past couple of decades, and they will only be seen to improve. This review paper provides an overview on the different techniques that use RNA-based approaches in the field of diagnostics and therapeutics.

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来源期刊
RNA Biology
RNA Biology 生物-生化与分子生物学
CiteScore
8.60
自引率
0.00%
发文量
82
审稿时长
1 months
期刊介绍: RNA has played a central role in all cellular processes since the beginning of life: decoding the genome, regulating gene expression, mediating molecular interactions, catalyzing chemical reactions. RNA Biology, as a leading journal in the field, provides a platform for presenting and discussing cutting-edge RNA research. RNA Biology brings together a multidisciplinary community of scientists working in the areas of: Transcription and splicing Post-transcriptional regulation of gene expression Non-coding RNAs RNA localization Translation and catalysis by RNA Structural biology Bioinformatics RNA in disease and therapy
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