Ting Ran, Yanni Wang, Fengxi Yuan, Ruoyi Liu, Meng Ye, Miao Zhang, Xia Du, Jing Zheng
{"title":"血清脂质特征与胰腺内脂肪沉积之间的性别相关性：一项横断面研究。","authors":"Ting Ran, Yanni Wang, Fengxi Yuan, Ruoyi Liu, Meng Ye, Miao Zhang, Xia Du, Jing Zheng","doi":"10.1186/s12944-024-02355-y","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Intra-pancreatic fat deposition (IPFD) is linked to metabolic and pancreatic diseases. MRI, while precise, is not cost-effective for routine IPFD screening, highlighting the need for accessible biomarkers. This study aims to analyze the relationships among serum lipid profiles, lipoprotein ratios, and IPFD, with a focus on sex differences.</p><p><strong>Methods: </strong>Data from adults at the Affiliated Hospital of Guizhou Medical University between 2018 and 2019 were analyzed. The subjects underwent routine Siemens 64-slice spiral CT scans, and IPFD was quantified via a quantitative computed tomography post-processing station. Lipid panel components were analyzed in the fasted state. Linear regression models stratified by gender were applied to evaluate these associations.</p><p><strong>Results: </strong>The study included 1,046 participants after exclusions, with significant sex differences found in the correlations between serum lipids, lipoprotein ratios, and IPFD. In females, remnant cholesterol was strongly associated with total IPFD (R2 = 0.155, P < 0.001), and similarly strong correlations existed with fat deposition in the pancreatic head (R<sup>2</sup> = 0.124, P = 0.003), body (R<sup>2</sup> = 0.102, P = 0.001), and tail (R<sup>2</sup> = 0.146, P = 0.005). Total cholesterol was also positively correlated with IPFD in females, particularly with the total IPFD (R<sup>2</sup> = 0.145, P = 0.002) and IPFD in the pancreatic head (R<sup>2</sup> = 0.177, P = 0.003) and body (R<sup>2</sup> = 0.100, P = 0.001). In males, triglycerides were notably correlated with IPFD in the tail (R<sup>2</sup> = 0.200, P = 0.045), but not in other regions. Similarly, total cholesterol was correlated with IPFD in the tail (R<sup>2</sup> = 0.197, P = 0.041). Additionally, in males, the triglyceride/high-density lipoprotein cholesterol ratio showed a positive association with tail fat deposition (R<sup>2</sup> = 0.200, P = 0.033).</p><p><strong>Conclusion: </strong>Significant differences between genders were evident in the correlations of serum lipids and lipoprotein ratios with IPFD. In women, remnant cholesterol was strongly correlated with IPFD, suggesting its potential as a biomarker.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"384"},"PeriodicalIF":3.9000,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697053/pdf/","citationCount":"0","resultStr":"{\"title\":\"Gender-specific correlations between serum lipid profiles and intra-pancreatic fat deposition: a cross-sectional study.\",\"authors\":\"Ting Ran, Yanni Wang, Fengxi Yuan, Ruoyi Liu, Meng Ye, Miao Zhang, Xia Du, Jing Zheng\",\"doi\":\"10.1186/s12944-024-02355-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Intra-pancreatic fat deposition (IPFD) is linked to metabolic and pancreatic diseases. MRI, while precise, is not cost-effective for routine IPFD screening, highlighting the need for accessible biomarkers. This study aims to analyze the relationships among serum lipid profiles, lipoprotein ratios, and IPFD, with a focus on sex differences.</p><p><strong>Methods: </strong>Data from adults at the Affiliated Hospital of Guizhou Medical University between 2018 and 2019 were analyzed. The subjects underwent routine Siemens 64-slice spiral CT scans, and IPFD was quantified via a quantitative computed tomography post-processing station. Lipid panel components were analyzed in the fasted state. Linear regression models stratified by gender were applied to evaluate these associations.</p><p><strong>Results: </strong>The study included 1,046 participants after exclusions, with significant sex differences found in the correlations between serum lipids, lipoprotein ratios, and IPFD. In females, remnant cholesterol was strongly associated with total IPFD (R2 = 0.155, P < 0.001), and similarly strong correlations existed with fat deposition in the pancreatic head (R<sup>2</sup> = 0.124, P = 0.003), body (R<sup>2</sup> = 0.102, P = 0.001), and tail (R<sup>2</sup> = 0.146, P = 0.005). Total cholesterol was also positively correlated with IPFD in females, particularly with the total IPFD (R<sup>2</sup> = 0.145, P = 0.002) and IPFD in the pancreatic head (R<sup>2</sup> = 0.177, P = 0.003) and body (R<sup>2</sup> = 0.100, P = 0.001). In males, triglycerides were notably correlated with IPFD in the tail (R<sup>2</sup> = 0.200, P = 0.045), but not in other regions. Similarly, total cholesterol was correlated with IPFD in the tail (R<sup>2</sup> = 0.197, P = 0.041). Additionally, in males, the triglyceride/high-density lipoprotein cholesterol ratio showed a positive association with tail fat deposition (R<sup>2</sup> = 0.200, P = 0.033).</p><p><strong>Conclusion: </strong>Significant differences between genders were evident in the correlations of serum lipids and lipoprotein ratios with IPFD. In women, remnant cholesterol was strongly correlated with IPFD, suggesting its potential as a biomarker.</p>\",\"PeriodicalId\":18073,\"journal\":{\"name\":\"Lipids in Health and Disease\",\"volume\":\"23 1\",\"pages\":\"384\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-01-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697053/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lipids in Health and Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12944-024-02355-y\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lipids in Health and Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12944-024-02355-y","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景：胰腺内脂肪沉积（IPFD）与代谢性和胰腺疾病有关。MRI虽然精确，但在常规IPFD筛查中成本效益不高，这突出了对可获得的生物标志物的需求。本研究旨在分析血清脂质谱、脂蛋白比率与IPFD之间的关系，并重点分析性别差异。方法：对2018 - 2019年贵州医科大学附属医院的成人数据进行分析。受试者接受常规西门子64排螺旋CT扫描，并通过定量计算机断层扫描后处理站定量IPFD。在禁食状态下分析脂质面板成分。采用按性别分层的线性回归模型来评估这些关联。结果：该研究在排除后纳入了1046名参与者，在血脂、脂蛋白比率和IPFD之间的相关性中发现了显著的性别差异。在女性中，残余胆固醇与总IPFD （R2 = 0.155, P 2 = 0.124, P = 0.003）、身体（R2 = 0.102, P = 0.001）和尾巴（R2 = 0.146, P = 0.005）密切相关。总胆固醇也与女性IPFD呈正相关，尤其是与总IPFD （R2 = 0.145, P = 0.002）、胰腺头部IPFD （R2 = 0.177, P = 0.003）和身体IPFD （R2 = 0.100, P = 0.001）呈正相关。在雄性中，甘油三酯与尾部IPFD显著相关（R2 = 0.200, P = 0.045），但在其他区域不相关。同样，尾部总胆固醇与IPFD相关（R2 = 0.197, P = 0.041）。此外，在雄性中，甘油三酯/高密度脂蛋白胆固醇比值与尾部脂肪沉积呈正相关（R2 = 0.200, P = 0.033）。结论：血脂、脂蛋白比值与IPFD的相关性在性别间存在显著差异。在女性中，残余胆固醇与IPFD密切相关，表明其作为生物标志物的潜力。
Gender-specific correlations between serum lipid profiles and intra-pancreatic fat deposition: a cross-sectional study.
Background: Intra-pancreatic fat deposition (IPFD) is linked to metabolic and pancreatic diseases. MRI, while precise, is not cost-effective for routine IPFD screening, highlighting the need for accessible biomarkers. This study aims to analyze the relationships among serum lipid profiles, lipoprotein ratios, and IPFD, with a focus on sex differences.
Methods: Data from adults at the Affiliated Hospital of Guizhou Medical University between 2018 and 2019 were analyzed. The subjects underwent routine Siemens 64-slice spiral CT scans, and IPFD was quantified via a quantitative computed tomography post-processing station. Lipid panel components were analyzed in the fasted state. Linear regression models stratified by gender were applied to evaluate these associations.
Results: The study included 1,046 participants after exclusions, with significant sex differences found in the correlations between serum lipids, lipoprotein ratios, and IPFD. In females, remnant cholesterol was strongly associated with total IPFD (R2 = 0.155, P < 0.001), and similarly strong correlations existed with fat deposition in the pancreatic head (R2 = 0.124, P = 0.003), body (R2 = 0.102, P = 0.001), and tail (R2 = 0.146, P = 0.005). Total cholesterol was also positively correlated with IPFD in females, particularly with the total IPFD (R2 = 0.145, P = 0.002) and IPFD in the pancreatic head (R2 = 0.177, P = 0.003) and body (R2 = 0.100, P = 0.001). In males, triglycerides were notably correlated with IPFD in the tail (R2 = 0.200, P = 0.045), but not in other regions. Similarly, total cholesterol was correlated with IPFD in the tail (R2 = 0.197, P = 0.041). Additionally, in males, the triglyceride/high-density lipoprotein cholesterol ratio showed a positive association with tail fat deposition (R2 = 0.200, P = 0.033).
Conclusion: Significant differences between genders were evident in the correlations of serum lipids and lipoprotein ratios with IPFD. In women, remnant cholesterol was strongly correlated with IPFD, suggesting its potential as a biomarker.
期刊介绍：
Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds.
Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
