中国Eurya chinensis R. Br茎中3个具有潜在抗菌和抗新冠病毒活性的萜类化合物。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-01-02 DOI:10.1080/14786419.2024.2448204

Chen Liping, Lin Shaodan, Pan Yongchen, Huijun Liang, Chen Jiayan, Xin Lian, Li Guangying, Xiong Xiubi, Jie Yuan, Jiewei Wu

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引用次数: 0

摘要

芡实茎提取液。得到三种新萜（1-3），包括两种二萜和一种三萜，命名为euryachins C-E，以及三种已知的二萜（4-6）。这些新化合物的结构通过光谱分析，特别是红外光谱、核磁共振光谱和HRESIMS数据得到了证实。此外，对分离得到的化合物进行了对大肠杆菌、蜡样芽孢杆菌、金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌（MRSA）的抑菌活性评价。此外，我们还研究了分离得到的化合物对COVID-19的体外抑制活性。结果表明，化合物1 ~ 6具有较强的抗菌活性。其中化合物3和5的MIC值均为0.78µg/mL，抑菌活性与万古霉素相当。在抗covid -19检测中，化合物3-5的IC50值在4 ~ 8µM之间，与阳性对照相当。

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Three new terpenes with potential antibacterial and anti-COVID-19 activities from the stems of Eurya chinensis R. Br.

The extract of the stems of Eurya chinensis R. Br. yielded three new terpenes (1-3) including two diterpenes and one triterpene, named euryachins C-E, as well as three known diterpenes (4-6). The structures of these novel compounds were elucidated via spectroscopic analysis, especially IR, NMR spectroscopy and HRESIMS data. Besides, all the isolated compounds were evaluated for antibacterial activity against Escherichia coli, Bacillus cereus, Staphylococcus aureus and Methicillin-resistant S. aureus (MRSA). Additionally, the inhibitive activity of the isolated compounds against COVID-19 was studied in vitro. As a result, compounds 1-6 were endowed with profound antibacterial activity. Especially, the MIC values of compounds 3 and 5 both were 0.78 µg/mL, the same antibacterial activity as Vancomycin. In the anti-COVID-19 assay, the IC₅₀ values of compounds 3-5 were ranging from 4 to 8 µM, which were equivalent to the positive control.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.