人工智能的生物医学应用:几十年研究综述。

IF 4.3 4区 医学 Q1 PHARMACOLOGY & PHARMACY
Sweet Naskar, Suraj Sharma, Ketousetuo Kuotsu, Suman Halder, Goutam Pal, Subhankar Saha, Shubhadeep Mondal, Ujjwal Kumar Biswas, Mayukh Jana, Sunirmal Bhattacharjee
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引用次数: 0

摘要

计算机科学的一个重要领域被称为人工智能(AI),它成功地应用于分析复杂的生物数据,并从各种生物医学用途的数据集中提取实质性的关联。人工智能因其特点而引起了生物医学研究的极大兴趣:(i)通过早期诊断和检测改善患者护理;(ii)改进工作流程;㈢减少医疗差错;(五)降低医疗费用;(六)降低发病率和死亡率;(vii)提高业绩;(八)提高精确度;(九)时间效率。定量指标对于评估人工智能实施、提供见解、实现知情决策和衡量人工智能驱动计划的影响至关重要,从而提高透明度、问责制和整体影响。人工智能在生物医学领域的实施面临着伦理和隐私问题、缺乏意识、技术不可靠和专业责任等挑战。简要讨论了人工智能技术,包括虚拟筛选(VS), DL, ML,隐马尔可夫模型(hmm),神经网络(NNs),生成模型(GMs),分子动力学(MD)和构效关系(SAR)模型。本研究探讨了人工智能在生物医学领域的应用,重点介绍了人工智能在预测准确性、治疗疗效、诊断效率、更快决策、个性化治疗策略和精准医疗干预等方面的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The biomedical applications of artificial intelligence: an overview of decades of research.

A significant area of computer science called artificial intelligence (AI) is successfully applied to the analysis of intricate biological data and the extraction of substantial associations from datasets for a variety of biomedical uses. AI has attracted significant interest in biomedical research due to its features: (i) better patient care through early diagnosis and detection; (ii) enhanced workflow; (iii) lowering medical errors; (v) lowering medical costs; (vi) reducing morbidity and mortality; (vii) enhancing performance; (viii) enhancing precision; and (ix) time efficiency. Quantitative metrics are crucial for evaluating AI implementations, providing insights, enabling informed decisions, and measuring the impact of AI-driven initiatives, thereby enhancing transparency, accountability, and overall impact. The implementation of AI in biomedical fields faces challenges such as ethical and privacy concerns, lack of awareness, technology unreliability, and professional liability. A brief discussion is given of the AI techniques, which include Virtual screening (VS), DL, ML, Hidden Markov models (HMMs), Neural networks (NNs), Generative models (GMs), Molecular dynamics (MD), and Structure-activity relationship (SAR) models. The study explores the application of AI in biomedical fields, highlighting its enhanced predictive accuracy, treatment efficacy, diagnostic efficiency, faster decision-making, personalised treatment strategies, and precise medical interventions.

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来源期刊
CiteScore
9.10
自引率
0.00%
发文量
165
审稿时长
2 months
期刊介绍: Journal of Drug Targeting publishes papers and reviews on all aspects of drug delivery and targeting for molecular and macromolecular drugs including the design and characterization of carrier systems (whether colloidal, protein or polymeric) for both vitro and/or in vivo applications of these drugs. Papers are not restricted to drugs delivered by way of a carrier, but also include studies on molecular and macromolecular drugs that are designed to target specific cellular or extra-cellular molecules. As such the journal publishes results on the activity, delivery and targeting of therapeutic peptides/proteins and nucleic acids including genes/plasmid DNA, gene silencing nucleic acids (e.g. small interfering (si)RNA, antisense oligonucleotides, ribozymes, DNAzymes), as well as aptamers, mononucleotides and monoclonal antibodies and their conjugates. The diagnostic application of targeting technologies as well as targeted delivery of diagnostic and imaging agents also fall within the scope of the journal. In addition, papers are sought on self-regulating systems, systems responsive to their environment and to external stimuli and those that can produce programmed, pulsed and otherwise complex delivery patterns.
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