Hailong Li, Jianfeng Qiu, Zhe Gao, Chun Li, Jianjun Chu
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Data on various demographic and clinical parameters, including age, gender, race, poverty income ratio, educational level, smoking status, drinking status, cardiovascular disease, hypertension, diabetes mellitus, hemoglobin A1c, alanine transaminase, aspartate transaminase, serum total bilirubin, serum creatinine, uric acid, blood urea nitrogen, serum sodium, serum phosphorus, total calcium, serum potassium, and serum iron, were collected from all participants. The main analytical methods utilized in this study were multivariable logistic regression, restricted cubic splines, and threshold effect analysis to investigate the association between WHtR and OP.</p><p><strong>Results: </strong>A total of 5,746 elderly participants were enrolled, with a median age of 69.3 years. Compared with individuals with lower WHtR Q1 (≤0.36 to ≤0.56), the adjusted OR values for WHtR and OP in Q2 (<0.56 to ≤0.61), Q3 (<0.61 to ≤0.66), and Q4 (<0.66 to ≤ 0.94) were 0.63 (95% CI: 0.47-0.85, <i>p</i> = 0.003), 0.53 (95% CI: 0.37-0.76, <i>p</i> < 0.001), and 0.49 (95% CI: 0.35-0.68, <i>p</i> < 0.001), respectively. The association between WHtR and OP exhibited an L-shaped curve (nonlinear, <i>p</i> = 0.008) with an inflection point of roughly 0.57. The OR for the presence of OP was 0.50 (95% CI: 0.31-0.82, <i>p</i> = 0.007) in participants with WHtR <0.57. There was no association between WHtR and OP in participants with WHtR ≥0.57.</p><p><strong>Conclusion: </strong>The association between WHtR and OP showed an L-shaped curve, with an inflection point at around 0.57.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"11 ","pages":"1486611"},"PeriodicalIF":3.1000,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11688312/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association between waist-to-height ratio and osteoporosis in the National Health and Nutrition Examination Survey: a cross-sectional study.\",\"authors\":\"Hailong Li, Jianfeng Qiu, Zhe Gao, Chun Li, Jianjun Chu\",\"doi\":\"10.3389/fmed.2024.1486611\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The link between waist-to-height ratio (WHtR) and osteoporosis (OP) remains a contentious issue in the field of medical research. Currently, the available evidence on this association is deemed insufficient. This topic has garnered significant attention and is a focal point of ongoing investigations.</p><p><strong>Methods: </strong>A retrospective cross-sectional study was conducted, involving 5,746 participants from the National Health and Nutrition Examination Survey. Data on various demographic and clinical parameters, including age, gender, race, poverty income ratio, educational level, smoking status, drinking status, cardiovascular disease, hypertension, diabetes mellitus, hemoglobin A1c, alanine transaminase, aspartate transaminase, serum total bilirubin, serum creatinine, uric acid, blood urea nitrogen, serum sodium, serum phosphorus, total calcium, serum potassium, and serum iron, were collected from all participants. The main analytical methods utilized in this study were multivariable logistic regression, restricted cubic splines, and threshold effect analysis to investigate the association between WHtR and OP.</p><p><strong>Results: </strong>A total of 5,746 elderly participants were enrolled, with a median age of 69.3 years. Compared with individuals with lower WHtR Q1 (≤0.36 to ≤0.56), the adjusted OR values for WHtR and OP in Q2 (<0.56 to ≤0.61), Q3 (<0.61 to ≤0.66), and Q4 (<0.66 to ≤ 0.94) were 0.63 (95% CI: 0.47-0.85, <i>p</i> = 0.003), 0.53 (95% CI: 0.37-0.76, <i>p</i> < 0.001), and 0.49 (95% CI: 0.35-0.68, <i>p</i> < 0.001), respectively. The association between WHtR and OP exhibited an L-shaped curve (nonlinear, <i>p</i> = 0.008) with an inflection point of roughly 0.57. The OR for the presence of OP was 0.50 (95% CI: 0.31-0.82, <i>p</i> = 0.007) in participants with WHtR <0.57. 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引用次数: 0
摘要
背景：腰高比（WHtR）与骨质疏松症（OP）之间的关系在医学研究领域一直是一个有争议的问题。目前，这种关联的现有证据被认为是不足的。这个话题引起了极大的关注，是正在进行的研究的焦点。方法：采用回顾性横断面研究，纳入5746名来自全国健康与营养检查调查的参与者。收集所有参与者的年龄、性别、种族、贫困收入比、教育程度、吸烟状况、饮酒状况、心血管疾病、高血压、糖尿病、血红蛋白A1c、丙氨酸转氨酶、天冬氨酸转氨酶、血清总胆红素、血清肌酐、尿酸、血尿素氮、血清钠、血清磷、总钙、血清钾、血清铁等各种人口统计学和临床参数的数据。本研究主要采用多变量logistic回归、限制三次样条和阈值效应分析等分析方法，探讨WHtR与op的关系。结果：共纳入5746例老年人，中位年龄为69.3 岁。与WHtR Q1较低个体（≤0.36 ~≤0.56）相比，Q2的WHtR和OP的调整OR值（p = 0.003）为0.53 (95% CI: 0.37 ~ 0.76, p p p = 0.008)，拐点约为0.57。WHtR患者OP存在的OR为0.50 （95% CI: 0.31-0.82, p = 0.007）。结论：WHtR与OP的相关性呈l型曲线，拐点在0.57左右。
Association between waist-to-height ratio and osteoporosis in the National Health and Nutrition Examination Survey: a cross-sectional study.
Background: The link between waist-to-height ratio (WHtR) and osteoporosis (OP) remains a contentious issue in the field of medical research. Currently, the available evidence on this association is deemed insufficient. This topic has garnered significant attention and is a focal point of ongoing investigations.
Methods: A retrospective cross-sectional study was conducted, involving 5,746 participants from the National Health and Nutrition Examination Survey. Data on various demographic and clinical parameters, including age, gender, race, poverty income ratio, educational level, smoking status, drinking status, cardiovascular disease, hypertension, diabetes mellitus, hemoglobin A1c, alanine transaminase, aspartate transaminase, serum total bilirubin, serum creatinine, uric acid, blood urea nitrogen, serum sodium, serum phosphorus, total calcium, serum potassium, and serum iron, were collected from all participants. The main analytical methods utilized in this study were multivariable logistic regression, restricted cubic splines, and threshold effect analysis to investigate the association between WHtR and OP.
Results: A total of 5,746 elderly participants were enrolled, with a median age of 69.3 years. Compared with individuals with lower WHtR Q1 (≤0.36 to ≤0.56), the adjusted OR values for WHtR and OP in Q2 (<0.56 to ≤0.61), Q3 (<0.61 to ≤0.66), and Q4 (<0.66 to ≤ 0.94) were 0.63 (95% CI: 0.47-0.85, p = 0.003), 0.53 (95% CI: 0.37-0.76, p < 0.001), and 0.49 (95% CI: 0.35-0.68, p < 0.001), respectively. The association between WHtR and OP exhibited an L-shaped curve (nonlinear, p = 0.008) with an inflection point of roughly 0.57. The OR for the presence of OP was 0.50 (95% CI: 0.31-0.82, p = 0.007) in participants with WHtR <0.57. There was no association between WHtR and OP in participants with WHtR ≥0.57.
Conclusion: The association between WHtR and OP showed an L-shaped curve, with an inflection point at around 0.57.
期刊介绍：
Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate
- the use of patient-reported outcomes under real world conditions
- the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines
- the scientific bases for guidelines and decisions from regulatory authorities
- access to medicinal products and medical devices worldwide
- addressing the grand health challenges around the world
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