2000-2019年2型糖尿病患者和非2型糖尿病患者缺血性和非缺血性心力衰竭发病率趋势：英国的一项观察性研究

IF 6.1 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-02-01 DOI:10.1016/j.diabres.2024.111980

Kajal Panchal , Claire Lawson , Sharmin Shabnam , Kamlesh Khunti , Francesco Zaccardi

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引用次数: 0

摘要

目的：调查2000年1月1日至2019年12月31日期间英国2型糖尿病和非糖尿病成人缺血性和非缺血性心力衰竭（HF）的趋势。方法：我们使用临床实践研究数据链数据集，与医院发作统计和国家统计办公室相关联，估计每日历年10 年的缺血性和非缺血性心力衰竭发生率。结果：在735,810人的队列中，在中位随访10 年期间，记录了5,073例缺血性HF事件（2型糖尿病患者2,038例，无2型糖尿病患者3,035例）和16,501例非缺血性HF事件（分别为6,358例和10,143例）。从2000年到2004年到2005-2009年，缺血性HF的年龄标准化率略有下降，而非缺血性HF的发病率保持稳定，并且与糖尿病状态或性别无关，非缺血性HF的发病率始终高于缺血性HF。在考虑了人口统计学、合并症和药物方面的差异后，调整后的发病率比对趋势的影响可以忽略不计。结论：在英国，改善心衰预防和管理策略对于降低普通人群心衰风险和减少与2型糖尿病相关的持续风险差距至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Incidence trends in ischaemic and non-ischaemic heart failure in people with and without type 2 diabetes, 2000–2019: An observational study in England

Aim

To investigate trends in ischaemic and non-ischaemic heart failure (HF) in adults with type 2 diabetes and without diabetes between 1st January 2000 and 31st December 2019 in England.

Methods

We used the Clinical Practice Research Datalink datasets, linked to the Hospital Episode Statistics and Office for National Statistics, to estimate sex-specific crude and age-standardised rates of incident ischaemic and non-ischaemic HF up to 10 years per calendar year of diabetes diagnosis and diabetes status.

Results

In a cohort of 735,810 individuals, 5,073 ischaemic (2,038 in people with type 2 diabetes and 3,035 in those without) and 16,501 non-ischaemic (6,358 and 10,143, respectively) HF events were recorded during a median follow-up of 10 years. From 2000 to 2004 to 2005–2009, the age-standardised rates of ischaemic HF marginally declined, while rates remained stable for non-ischaemic HF and were consistently higher for non-ischaemic than ischaemic HF, regardless of diabetes status or sex. Adjusted incidence rate ratios demonstrated negligible impact on trends after accounting for differences in demographics, comorbidities and medications.

Conclusions

Improving HF prevention and management strategies remains crucial to decrease the risk of HF in the general population and reduce the persistent risk-gap associated with type 2 diabetes in England.

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.