{"title":"大蒜素对墨西哥高原肉鸡腹水综合征性状和血管紧张素ii型1受体基因表达的影响","authors":"Artemio Jovanny Vargas-Galicia, Raúl Argüello-García, Arturo Pro-Martínez, Fernando González-Cerón, Amalio Santacruz-Varela, Horacio Osorio-Alonso, Eliseo Sosa-Montes","doi":"10.1080/03079457.2024.2447284","DOIUrl":null,"url":null,"abstract":"<p><p>Ascites syndrome (AS) is a deadly condition in fast-growing chickens, preceded by pulmonary arterial hypertension (PAH), where the angiotensin II type 1 receptor (ATR1) plays a role. We investigated whether allicin (ALLI), a garlic derivative, could (a) interact with broiler ATR1, (b) affect ascites-related traits [haematocrit content (Hct%), blood oxygen saturation (SaO<sub>2</sub>), and the right-to-total ventricular weight ratio (RV:TV)], (c) modify ATR1 expression in the lung, heart, and liver, alongside ascites mortality and growth performance in Ross 308 broilers raised at high altitude and under cold temperatures promoting PAH/AS. Three groups (<i>n</i> = 70 each) were studied: 0-ALLI (untreated), 1-ALLI (allicin 1 mg/kg bodyweight/daily at 14-27 days of age by oral-oesophageal route), and 2.5-ALLI. After 3-6 weeks, Hct%, SaO<sub>2</sub>, RV:TV ratios, and ATR1 expression in the lung, heart, and liver, were evaluated. Weekly productive performance and AS mortality were recorded. Molecular dockings and dynamic simulations predicted that ALLI might inhibit broiler ATR1 in a transitory manner. At 42 days of age, birds in the 2.5-ALLI group exhibited lower Hct% and lower RV:TV values, while ALLI marginally enhanced SaO<sub>2</sub>. ATR1 expression in the 1-ALLI and 2.5-ALLI groups was higher (i.e. restored) in the lungs and heart, respectively, but not in the liver compared with the untreated group. Productive performance remained unaffected by ALLI, and 2.5-ALLI provided a protection of 4.3% against ascites mortality. In conclusion, 2.5-ALLI mitigated PAH/AS traits in the lungs and heart without compromising broiler productive performance. Further studies adjusting ALLI doses and combinations are warranted. RESEARCH HIGHLIGHTSBroilers bred at >2000 m OSL and <20°C were treated with 1 or 2.5 mg allicin <i>per os</i>.Allicin at 2.5 mg <i>per os</i> decreased haematocrit and right ventricular hypertrophy.Allicin treatments restored ATR1 expression in the heart and lungs.Productive performance of broilers was not affected by allicin treatments.Allicin is a promising candidate to enhance the quality of poultry production.</p>","PeriodicalId":8788,"journal":{"name":"Avian Pathology","volume":" ","pages":"1-12"},"PeriodicalIF":2.5000,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of allicin on ascites syndrome traits and angiotensin II type 1 receptor gene expression in broilers reared in the Mexican highlands.\",\"authors\":\"Artemio Jovanny Vargas-Galicia, Raúl Argüello-García, Arturo Pro-Martínez, Fernando González-Cerón, Amalio Santacruz-Varela, Horacio Osorio-Alonso, Eliseo Sosa-Montes\",\"doi\":\"10.1080/03079457.2024.2447284\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Ascites syndrome (AS) is a deadly condition in fast-growing chickens, preceded by pulmonary arterial hypertension (PAH), where the angiotensin II type 1 receptor (ATR1) plays a role. We investigated whether allicin (ALLI), a garlic derivative, could (a) interact with broiler ATR1, (b) affect ascites-related traits [haematocrit content (Hct%), blood oxygen saturation (SaO<sub>2</sub>), and the right-to-total ventricular weight ratio (RV:TV)], (c) modify ATR1 expression in the lung, heart, and liver, alongside ascites mortality and growth performance in Ross 308 broilers raised at high altitude and under cold temperatures promoting PAH/AS. Three groups (<i>n</i> = 70 each) were studied: 0-ALLI (untreated), 1-ALLI (allicin 1 mg/kg bodyweight/daily at 14-27 days of age by oral-oesophageal route), and 2.5-ALLI. After 3-6 weeks, Hct%, SaO<sub>2</sub>, RV:TV ratios, and ATR1 expression in the lung, heart, and liver, were evaluated. Weekly productive performance and AS mortality were recorded. Molecular dockings and dynamic simulations predicted that ALLI might inhibit broiler ATR1 in a transitory manner. At 42 days of age, birds in the 2.5-ALLI group exhibited lower Hct% and lower RV:TV values, while ALLI marginally enhanced SaO<sub>2</sub>. ATR1 expression in the 1-ALLI and 2.5-ALLI groups was higher (i.e. restored) in the lungs and heart, respectively, but not in the liver compared with the untreated group. Productive performance remained unaffected by ALLI, and 2.5-ALLI provided a protection of 4.3% against ascites mortality. In conclusion, 2.5-ALLI mitigated PAH/AS traits in the lungs and heart without compromising broiler productive performance. Further studies adjusting ALLI doses and combinations are warranted. RESEARCH HIGHLIGHTSBroilers bred at >2000 m OSL and <20°C were treated with 1 or 2.5 mg allicin <i>per os</i>.Allicin at 2.5 mg <i>per os</i> decreased haematocrit and right ventricular hypertrophy.Allicin treatments restored ATR1 expression in the heart and lungs.Productive performance of broilers was not affected by allicin treatments.Allicin is a promising candidate to enhance the quality of poultry production.</p>\",\"PeriodicalId\":8788,\"journal\":{\"name\":\"Avian Pathology\",\"volume\":\" \",\"pages\":\"1-12\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-01-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Avian Pathology\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1080/03079457.2024.2447284\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Avian Pathology","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1080/03079457.2024.2447284","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Effects of allicin on ascites syndrome traits and angiotensin II type 1 receptor gene expression in broilers reared in the Mexican highlands.
Ascites syndrome (AS) is a deadly condition in fast-growing chickens, preceded by pulmonary arterial hypertension (PAH), where the angiotensin II type 1 receptor (ATR1) plays a role. We investigated whether allicin (ALLI), a garlic derivative, could (a) interact with broiler ATR1, (b) affect ascites-related traits [haematocrit content (Hct%), blood oxygen saturation (SaO2), and the right-to-total ventricular weight ratio (RV:TV)], (c) modify ATR1 expression in the lung, heart, and liver, alongside ascites mortality and growth performance in Ross 308 broilers raised at high altitude and under cold temperatures promoting PAH/AS. Three groups (n = 70 each) were studied: 0-ALLI (untreated), 1-ALLI (allicin 1 mg/kg bodyweight/daily at 14-27 days of age by oral-oesophageal route), and 2.5-ALLI. After 3-6 weeks, Hct%, SaO2, RV:TV ratios, and ATR1 expression in the lung, heart, and liver, were evaluated. Weekly productive performance and AS mortality were recorded. Molecular dockings and dynamic simulations predicted that ALLI might inhibit broiler ATR1 in a transitory manner. At 42 days of age, birds in the 2.5-ALLI group exhibited lower Hct% and lower RV:TV values, while ALLI marginally enhanced SaO2. ATR1 expression in the 1-ALLI and 2.5-ALLI groups was higher (i.e. restored) in the lungs and heart, respectively, but not in the liver compared with the untreated group. Productive performance remained unaffected by ALLI, and 2.5-ALLI provided a protection of 4.3% against ascites mortality. In conclusion, 2.5-ALLI mitigated PAH/AS traits in the lungs and heart without compromising broiler productive performance. Further studies adjusting ALLI doses and combinations are warranted. RESEARCH HIGHLIGHTSBroilers bred at >2000 m OSL and <20°C were treated with 1 or 2.5 mg allicin per os.Allicin at 2.5 mg per os decreased haematocrit and right ventricular hypertrophy.Allicin treatments restored ATR1 expression in the heart and lungs.Productive performance of broilers was not affected by allicin treatments.Allicin is a promising candidate to enhance the quality of poultry production.
期刊介绍：
Avian Pathology is the official journal of the World Veterinary Poultry Association and, since its first publication in 1972, has been a leading international journal for poultry disease scientists. It publishes material relevant to the entire field of infectious and non-infectious diseases of poultry and other birds. Accepted manuscripts will contribute novel data of interest to an international readership and will add significantly to knowledge and understanding of diseases, old or new. Subject areas include pathology, diagnosis, detection and characterisation of pathogens, infections of possible zoonotic importance, epidemiology, innate and immune responses, vaccines, gene sequences, genetics in relation to disease and physiological and biochemical changes in response to disease. First and subsequent reports of well-recognized diseases within a country are not acceptable unless they also include substantial new information about the disease or pathogen. Manuscripts on wild or pet birds should describe disease or pathogens in a significant number of birds, recognizing/suggesting serious potential impact on that species or that the disease or pathogen is of demonstrable relevance to poultry. Manuscripts on food-borne microorganisms acquired during or after processing, and those that catalogue the occurrence or properties of microorganisms, are unlikely to be considered for publication in the absence of data linking them to avian disease.
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