对SARS-cov-2变体具有广谱保护的工程mRNA疫苗

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical and biophysical research communications Pub Date : 2025-02-01 DOI:10.1016/j.bbrc.2024.151224

Shuang Du , Liu Yang , Xingguang Chen , Yonghao Chen , Liang Weng , Hui Huang , Silin Pang

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引用次数: 0

摘要

通过大规模疫苗接种进行群体免疫是预防传染病的有效方法。然而，新出现的频繁突变的SARS-CoV-2变体在很大程度上逃避了COVID-19疫苗诱导的免疫反应和保护。在这里，我们设计了编码各种COVID-19变体共享的刺突蛋白突变表位的信使rna。这些mrna被包裹在脂质纳米颗粒中，形成一种名为“mPANVAX@COVID”的疫苗。接种疫苗后，该方法可对多种SARS-CoV-2变体（包括Delta和Omicron）产生有效免疫，并显示出良好的安全性。本研究为广泛保护性疫苗的设计提供了新的方向。

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Engineering mRNA vaccine with broad-spectrum protection against SARS-cov-2 variants

Herd immunity through mass vaccination is an effective method for preventing infectious diseases. However, the emerging SARS-CoV-2 variants, with their frequent mutations, largely evade the immune response and protection induced by COVID-19 vaccines. Here, we designed messenger RNAs encoding mutant epitopes of the spike protein shared among various COVID-19 variants. These mRNAs were encapsulated in lipid nanoparticles to formulate a vaccine named ‘mPANVAX@COVID'. Post-vaccination, this approach elicited effective immunity against multiple SARS-CoV-2 variants, including Delta and Omicron, and demonstrated good safety. This study suggests a novel direction for the design of broadly protective vaccines.

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来源期刊

Biochemical and biophysical research communications 生物-生化与分子生物学

CiteScore

6.10

自引率

0.00%

发文量

1400

审稿时长

14 days

期刊介绍： Biochemical and Biophysical Research Communications is the premier international journal devoted to the very rapid dissemination of timely and significant experimental results in diverse fields of biological research. The development of the "Breakthroughs and Views" section brings the minireview format to the journal, and issues often contain collections of special interest manuscripts. BBRC is published weekly (52 issues/year).Research Areas now include: Biochemistry; biophysics; cell biology; developmental biology; immunology ; molecular biology; neurobiology; plant biology and proteomics