Flemming Javier Olsen, Nino Emanuel Landler, Jacob Christensen, Klaus Fuglsang Kofoed, Bo Feldt-Rasmussen, Ditte Hansen, Christina Christoffersen, Ellen Linnea Freese Ballegaard, Ida Maria Hjelm Sørensen, Sasha Saurbrey Bjergfelt, Eline Seidelin, Susanne Bro, Tor Biering-Sørensen
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Logistic regression was applied to investigate the association between work measures and high CACS (>400).</p><p><strong>Results: </strong>We included 455 patients (age: 57 years, 60% men, 8% with previous CAD, and eGFR of 43 mL/min/1.73 m<sup>2</sup>). High CACS across all coronary arteries was observed in 77 (17%), with 53 (12%) in the left anterior descending (LAD) artery, 28 (6%) in the right coronary artery (RCA), and 17 (4%) in the circumflex (Cx) artery. No difference in GWI was observed for overall high versus non-high CACS (1861 vs. 1937 mmHg%, p = 0.14). TWI was reduced in patients with high versus non-high CACS in the LAD (1772 vs. 1956 mmHg%, p = 0.003) and in the Cx (1556 vs. 1934 mmHg%, p = 0.001), but not in the RCA (p = 0.68). After multivariable regression, TWI remained significantly associated with high CACS in the LAD and Cx in patients with no history of CAD, but not in the RCA.</p><p><strong>Conclusion: </strong>In patients with CKD, GWI was not associated with an overall high CACS. TWI was, however, associated with a high CACS in specific coronary arteries, although the findings were inconsistent.</p>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 1","pages":"e70064"},"PeriodicalIF":1.6000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association Between Myocardial Work and Coronary Artery Calcium Score in Patients With Chronic Kidney Disease.\",\"authors\":\"Flemming Javier Olsen, Nino Emanuel Landler, Jacob Christensen, Klaus Fuglsang Kofoed, Bo Feldt-Rasmussen, Ditte Hansen, Christina Christoffersen, Ellen Linnea Freese Ballegaard, Ida Maria Hjelm Sørensen, Sasha Saurbrey Bjergfelt, Eline Seidelin, Susanne Bro, Tor Biering-Sørensen\",\"doi\":\"10.1111/echo.70064\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Myocardial work is a novel measure of potential value for diagnosing coronary artery disease (CAD). 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No difference in GWI was observed for overall high versus non-high CACS (1861 vs. 1937 mmHg%, p = 0.14). TWI was reduced in patients with high versus non-high CACS in the LAD (1772 vs. 1956 mmHg%, p = 0.003) and in the Cx (1556 vs. 1934 mmHg%, p = 0.001), but not in the RCA (p = 0.68). After multivariable regression, TWI remained significantly associated with high CACS in the LAD and Cx in patients with no history of CAD, but not in the RCA.</p><p><strong>Conclusion: </strong>In patients with CKD, GWI was not associated with an overall high CACS. 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引用次数: 0
摘要
背景：心肌功是一种诊断冠状动脉疾病（CAD）的新方法。因此，它可能对慢性肾脏疾病（CKD）患者有用，在这些患者中，诊断工作可能具有挑战性。方法：这是一项CKD患者（G1-5，非透析依赖）的横断面研究。进行心脏计算机断层扫描，量化冠状动脉钙评分（CACS）。通过压力-应变环分析获得全局和区域工作指数（GWI和TWI）。采用Logistic回归研究工作措施与高CACS （bbb400）之间的关系。结果：我们纳入了455例患者（年龄：57岁，60%为男性，8%既往患有CAD， eGFR为43 mL/min/1.73 m2）。77例（17%）冠状动脉均出现高CACS，其中左前降支（LAD） 53例（12%），右冠状动脉（RCA） 28例（6%），旋支（Cx） 17例（4%）。总体高与非高CACS组GWI无差异（1861 vs 1937 mmHg%, p = 0.14）。在LAD （1772 vs. 1956 mmHg%, p = 0.003）和Cx （1556 vs. 1934 mmHg%, p = 0.001）的高CACS患者中，TWI减少（p = 0.68），但在RCA中没有（p = 0.68）。多变量回归后，TWI仍与无CAD病史的LAD和Cx患者的高CACS显著相关，但与RCA无关。结论：在CKD患者中，GWI与总体高CACS无关。然而，TWI与特定冠状动脉的高CACS有关，尽管研究结果不一致。
Association Between Myocardial Work and Coronary Artery Calcium Score in Patients With Chronic Kidney Disease.
Background: Myocardial work is a novel measure of potential value for diagnosing coronary artery disease (CAD). It may therefore be useful in patients with chronic kidney disease (CKD), in whom the diagnostic work-up can be challenging.
Methods: This was a cross-sectional study of patients with CKD (G1-5, nondialysis-dependent). Cardiac computed tomography was performed to quantify coronary artery calcium score (CACS). Pressure-strain loop analysis was performed to obtain global and territorial work index (GWI and TWI, respectively). Logistic regression was applied to investigate the association between work measures and high CACS (>400).
Results: We included 455 patients (age: 57 years, 60% men, 8% with previous CAD, and eGFR of 43 mL/min/1.73 m2). High CACS across all coronary arteries was observed in 77 (17%), with 53 (12%) in the left anterior descending (LAD) artery, 28 (6%) in the right coronary artery (RCA), and 17 (4%) in the circumflex (Cx) artery. No difference in GWI was observed for overall high versus non-high CACS (1861 vs. 1937 mmHg%, p = 0.14). TWI was reduced in patients with high versus non-high CACS in the LAD (1772 vs. 1956 mmHg%, p = 0.003) and in the Cx (1556 vs. 1934 mmHg%, p = 0.001), but not in the RCA (p = 0.68). After multivariable regression, TWI remained significantly associated with high CACS in the LAD and Cx in patients with no history of CAD, but not in the RCA.
Conclusion: In patients with CKD, GWI was not associated with an overall high CACS. TWI was, however, associated with a high CACS in specific coronary arteries, although the findings were inconsistent.
期刊介绍：
Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques is the official publication of the International Society of Cardiovascular Ultrasound. Widely recognized for its comprehensive peer-reviewed articles, case studies, original research, and reviews by international authors. Echocardiography keeps its readership of echocardiographers, ultrasound specialists, and cardiologists well informed of the latest developments in the field.
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