{"title":"催眠药、事故和伤害之间的关系：基于日本不良药物事件报告数据库的研究。","authors":"Rintaro Sogawa, Masakazu Hatano, Fumi Nishimura, Junya Nishi, Ayaka Matsuoka, Kota Shinada, Haruna Yamada, Hiroshi Tateishi, Yoshito Mizoguchi, Akira Monji, Chisato Shimanoe","doi":"10.21873/invivo.13846","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/aim: </strong>The use of hypnotic drugs can lead to accidents and injuries. However, few reports have shown their association with these events after adjusting for many concomitant medications. This study aimed to determine whether the use of hypnotic drugs was associated with accidents and injuries.</p><p><strong>Patients and methods: </strong>Using the Japanese Adverse Event Reporting Database, 772,387 reports published between September 2023 and April 2004 were analyzed. 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引用次数: 0
摘要
背景/目的：催眠药物的使用可能导致事故和伤害。然而，很少有报告显示，在调整了许多伴随药物后，它们与这些事件有关。这项研究旨在确定催眠药物的使用是否与事故和伤害有关。患者和方法：使用日本不良事件报告数据库，分析了2023年9月至2004年4月期间发表的772,387份报告。在调整潜在混杂因素后，计算每种催眠药物相关事故和伤害的报告优势比（RORs）和95%置信区间（ci）。结果：有12484例报告显示催眠药物与事故和伤害有关。每种催眠药物的使用都与事故、伤害和其他不良事件有关。然而，一项校正了年龄、性别、报告年份和伴随用药的多变量分析显示，褪黑激素受体激动剂的ROR显著降低(校正ROR=1.26；95%CI=1.03-1.55)和双食欲素受体拮抗剂（DORAs）(校正ROR=1.04；95% ci = 0.86 - -1.25)。特别是在dora中，观察到事故和伤害信号的丢失。结论：催眠药物的使用不同，事故和伤害的风险也不同；然而，dora与这些事件的关联可能不太频繁。本研究结果为催眠药物的选择提供了有用的信息。
Association Between Hypnotics, Accidents, and Injuries: A Study Based on the Adverse Drug Event Reporting Database in Japan.
Background/aim: The use of hypnotic drugs can lead to accidents and injuries. However, few reports have shown their association with these events after adjusting for many concomitant medications. This study aimed to determine whether the use of hypnotic drugs was associated with accidents and injuries.
Patients and methods: Using the Japanese Adverse Event Reporting Database, 772,387 reports published between September 2023 and April 2004 were analyzed. Reporting odds ratios (RORs) and 95% confidence intervals (CIs) for accidents and injuries associated with each hypnotic drug were calculated after adjusting for potential confounders.
Results: Of the total, 12,484 reports indicated association of hypnotic drugs with accidents and injuries. The use of each hypnotic drug was associated with accidents, injuries, and other adverse events. However, a multivariate analysis adjusted for age, sex, reporting year, and concomitant medications showed a considerable decrease in ROR for melatonin receptor agonists (adjusted ROR=1.26; 95%CI=1.03-1.55) and dual orexin receptor antagonists (DORAs) (adjusted ROR=1.04; 95%CI=0.86-1.25). Particularly in DORAs, a loss of signal for accidents and injuries was observed.
Conclusion: The risk of accidents and injuries may vary with hypnotic drug use; however, DORAs may be less frequently associated with these events. The results of this study provide useful information for the selection of hypnotic drugs.
期刊介绍：
IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management.
The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.
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