COVID-19大流行对多发性硬化症患者和普通人群健康相关生活质量的影响：一项利用EQ-5D-5L与社会心理锚点的比较研究

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior Pub Date : 2025-01-01 DOI:10.1002/brb3.70210

Glen J Henson, Ingrid van der Mei, Bruce V Taylor, Suzi B Claflin, Andrew J Palmer, Gang Chen, Julie A Campbell

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引用次数: 0

摘要

研究表明，多发性硬化症（PwMS）患者受到COVID-19大流行的严重影响。然而，没有研究比较COVID-19大流行对PwMS和普通人群的总体健康相关生活质量的影响。差异将对危机/大流行管理政策产生影响。本研究旨在比较与covid -19相关的逆境（如精神或身体健康恶化）在PwMS和普通人群中的患病率和与健康相关的生活质量影响。方法：从2020年8月至10月的澳大利亚普通人群研究（包括有和没有慢性疾病的亚样本）和澳大利亚多发性硬化纵向研究中获得横断面数据。与健康相关的生活质量采用健康状态效用(HSUs；以eq - 5d - 5l -心理社会量表产生的0（死亡）到1（完全健康）表示。通过专门的调查项目测量与covid -19相关的逆境。进行了描述性和多变量回归分析。结果：共有1020名普通人群和1635名MS参与者进入研究(平均年龄52.4岁和58.4岁；女性分别为52.4%和80.2%)。与患有和不患有慢性疾病的普通人群相比，PwMS中与covid -19相关的逆境患病率更高（PR: 1.430 [CI: 1.153, 1.774]和PR: 1.90 [CI: 1.56, 2.32]）。然而，与covid -19相关的逆境对HSU的影响并不依赖于疾病状态（p < 0.20，相互作用检验）。结论：本研究发现，与普通人群相比，PwMS更有可能经历与covid -19相关的逆境，尽管与健康相关的生活质量影响相似。这表明，在国家和全球危机期间，PwMS需要额外的支持。

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The Health-Related Quality of Life Impact of the COVID-19 Pandemic on People Living with Multiple Sclerosis and the General Population: A Comparative Study Utilizing the EQ-5D-5L with Psychosocial Bolt-Ons.

Objectives: Studies have shown that people living with multiple sclerosis (PwMS) were substantially impacted by the COVID-19 pandemic. However, no study has compared the overall health-related quality of life impact of the COVID-19 pandemic on PwMS and the general population. Differences would have implications for crises/pandemic management policies. This study aimed to compare the prevalence and health-related quality of life impact of COVID-19-related adversity (such as deteriorations in mental or physical health) in PwMS and the general population.

Methods: Cross-sectional data were obtained from the How Is Your Life Australian general population study (comprising subsamples with and without chronic disease) and the Australian MS Longitudinal Study from August to October 2020. Health-related quality of life was measured using health state utilities (HSUs; represented on a 0 [death] to 1 [full health] scale) generated by the EQ-5D-5L-Psychosocial. COVID-19-related adversity was measured via specialized survey items. Descriptive and multivariable regression analyses were conducted.

Results: A total of 1020 general population individuals and 1635 MS participants entered the study (mean age 52.4 and 58.4; female 52.4% and 80.2%, respectively). COVID-19-related adversity prevalence was higher among PwMS compared to the general population with and without chronic diseases (PR: 1.430 [CI: 1.153, 1.774] and PR: 1.90 [CI: 1.56, 2.32], respectively). However, the HSU impact of COVID-19-related adversity was not dependent on disease status (p > 0.20, test for interaction).

Conclusion: This study found that PwMS were more likely to experience COVID-19-related adversity compared to the general population, though the health-related quality-of-life impact was similar. This demonstrates that PwMS require additional support during national and global crises.

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

期刊介绍： Brain and Behavior is supported by other journals published by Wiley, including a number of society-owned journals. The journals listed below support Brain and Behavior and participate in the Manuscript Transfer Program by referring articles of suitable quality and offering authors the option to have their paper, with any peer review reports, automatically transferred to Brain and Behavior. * [Acta Psychiatrica Scandinavica](https://publons.com/journal/1366/acta-psychiatrica-scandinavica) * [Addiction Biology](https://publons.com/journal/1523/addiction-biology) * [Aggressive Behavior](https://publons.com/journal/3611/aggressive-behavior) * [Brain Pathology](https://publons.com/journal/1787/brain-pathology) * [Child: Care, Health and Development](https://publons.com/journal/6111/child-care-health-and-development) * [Criminal Behaviour and Mental Health](https://publons.com/journal/3839/criminal-behaviour-and-mental-health) * [Depression and Anxiety](https://publons.com/journal/1528/depression-and-anxiety) * Developmental Neurobiology * [Developmental Science](https://publons.com/journal/1069/developmental-science) * [European Journal of Neuroscience](https://publons.com/journal/1441/european-journal-of-neuroscience) * [Genes, Brain and Behavior](https://publons.com/journal/1635/genes-brain-and-behavior) * [GLIA](https://publons.com/journal/1287/glia) * [Hippocampus](https://publons.com/journal/1056/hippocampus) * [Human Brain Mapping](https://publons.com/journal/500/human-brain-mapping) * [Journal for the Theory of Social Behaviour](https://publons.com/journal/7330/journal-for-the-theory-of-social-behaviour) * [Journal of Comparative Neurology](https://publons.com/journal/1306/journal-of-comparative-neurology) * [Journal of Neuroimaging](https://publons.com/journal/6379/journal-of-neuroimaging) * [Journal of Neuroscience Research](https://publons.com/journal/2778/journal-of-neuroscience-research) * [Journal of Organizational Behavior](https://publons.com/journal/1123/journal-of-organizational-behavior) * [Journal of the Peripheral Nervous System](https://publons.com/journal/3929/journal-of-the-peripheral-nervous-system) * [Muscle & Nerve](https://publons.com/journal/4448/muscle-and-nerve) * [Neural Pathology and Applied Neurobiology](https://publons.com/journal/2401/neuropathology-and-applied-neurobiology)