免疫系统来源的mirna在心血管疾病中的功能。

IF 5.9 3区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Non-coding RNA Research Pub Date : 2024-11-14 DOI:10.1016/j.ncrna.2024.11.004

Albert Sufianov , Murad Agaverdiev , Andrey Mashkin , Tatiana Ilyasova

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引用次数: 0

摘要

心血管疾病（CVD）是世界范围内死亡的首要原因，免疫学的最新进展强调了免疫细胞在其发病和进展中的关键作用。microrna (mirna)，特别是那些来自免疫系统的，已经成为心血管系统中细胞功能的重要调节因子。这篇综述的重点是“免疫mirs”，一类在免疫细胞中高度表达的mirna，包括T细胞、B细胞、NK细胞、中性粒细胞和单核/巨噬细胞，以及它们在控制免疫信号通路中的重要作用。强调最近在人类和动物模型中的研究，本综述探讨了miRNAs如何影响先天和适应性免疫反应，并探讨了它们作为CVD治疗靶点的潜力。特别强调的是调节T细胞的miRNA，这表明靶向操纵这些miRNA通路可能为心血管疾病治疗提供新的策略。随着心血管免疫学研究的进展，本综述旨在全面概述免疫系统来源的mirna在改变心血管疾病管理和治疗方面的潜力，解决一项重大的全球健康挑战。

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The functions of immune system-derived miRNAs in cardiovascular diseases

Cardiovascular diseases (CVD) are the foremost cause of mortality worldwide, with recent advances in immunology underscoring the critical roles of immune cells in their onset and progression. MicroRNAs (miRNAs), particularly those derived from the immune system, have emerged as vital regulators of cellular functions within the cardiovascular landscape. This review focuses on "immuno-miRs," a class of miRNAs that are highly expressed in immune cells, including T cells, B cells, NK cells, neutrophils, and monocytes/macrophages, and their significant role in controlling immune signaling pathways. Highlighting recent studies in human and animal models, this review examines how miRNAs influence both innate and adaptive immune responses and explores their potential as therapeutic targets for CVD. Special emphasis is placed on miRNAs that regulate T cells, suggesting that targeted manipulation of these miRNA pathways could offer new strategies for CVD treatment. As research in cardiovascular immunology advances, this review aims to provide a thorough overview of the potential of immune system-derived miRNAs to revolutionize CVD management and therapy, addressing a major global health challenge.

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来源期刊

Non-coding RNA Research Medicine-Biochemistry (medical)

CiteScore

7.70

自引率

6.00%

发文量

审稿时长

49 days

期刊介绍： Non-coding RNA Research aims to publish high quality research and review articles on the mechanistic role of non-coding RNAs in all human diseases. This interdisciplinary journal will welcome research dealing with all aspects of non-coding RNAs-their biogenesis, regulation and role in disease progression. The focus of this journal will be to publish translational studies as well as well-designed basic studies with translational and clinical implications. The non-coding RNAs of particular interest will be microRNAs (miRNAs), small interfering RNAs (siRNAs), small nucleolar RNAs (snoRNAs), U-RNAs/small nuclear RNAs (snRNAs), exosomal/extracellular RNAs (exRNAs), Piwi-interacting RNAs (piRNAs) and long non-coding RNAs. Topics of interest will include, but not limited to: -Regulation of non-coding RNAs -Targets and regulatory functions of non-coding RNAs -Epigenetics and non-coding RNAs -Biological functions of non-coding RNAs -Non-coding RNAs as biomarkers -Non-coding RNA-based therapeutics -Prognostic value of non-coding RNAs -Pharmacological studies involving non-coding RNAs -Population based and epidemiological studies -Gene expression / proteomics / computational / pathway analysis-based studies on non-coding RNAs with functional validation -Novel strategies to manipulate non-coding RNAs expression and function -Clinical studies on evaluation of non-coding RNAs The journal will strive to disseminate cutting edge research, showcasing the ever-evolving importance of non-coding RNAs in modern day research and medicine.