富血小板纤维蛋白在牙槽嵴重建或引导骨再生过程中的有效性：一项系统回顾和荟萃分析。：肺泡嵴增高中富含血小板的纤维蛋白。

IF 4.8 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of dentistry Pub Date : 2025-02-01 DOI:10.1016/j.jdent.2024.105548

M. Arora , N. McAulay , A. Farag , ZS. Natto , J. Lu , R. Albuquerque , E M-C. Lu

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引用次数: 0

摘要

临床研究表明，使用富血小板纤维蛋白（PRF），无论是单独使用还是与生物材料联合使用，用于牙槽嵴重建（ARR）或引导骨再生（GBR），都有良好的效果。虽然PRF应用加速伤口愈合并减少术后不适，但其作为ARR或GBR的一部分对牙槽骨增重的影响尚不清楚。因此，本研究旨在探讨PRF用于ARR或GBR的临床疗效，以及这些手术后的术后不适。来源：使用系统评价和荟萃分析首选报告项目（PRISMA）方法进行系统搜索，包括MEDLINE （OVID接口，1946年起）、EMBASE （OVID接口，1974年起）和Global Health （OVID接口，1973年起）的数据库搜索。资料：在最初确定的74项研究中，有7项研究被纳入系统评价，包括6项随机对照试验（RCTs）和1项队列研究。meta分析显示，PRF作为ARR或GBR的一部分，导致水平脊宽增加，吸收增加率降低，而术后不适相同或略有改善。6项随机对照试验中只有1项偏倚质量风险低，纽卡斯尔渥太华量表评估显示队列研究质量高。结论：PRF应用于ARR或GBR可增加水平牙槽嵴宽度，降低移植物吸收率。然而，与这两个结果测量相关的发现是基于有限数量的研究。临床意义：PRF应用可有效作为ARR或GBR的一部分，增加水平嵴宽度，降低移植物吸收率。

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The Effectiveness of Platelet Rich Fibrin in Alveolar Ridge Reconstructive or Guided Bone Regenerative Procedures: A Systematic Review and Meta-Analysis

Introduction and Objectives

Clinical studies have shown favorable outcomes following use of platelet rich fibrin (PRF), either alone or in conjunction with biomaterials for alveolar ridge reconstruction (ARR) or guided bone regeneration (GBR) . While PRF application accelerates wound healing and reduces postoperative discomfort, its effects on the alveolar bone gain, as part of ARR or GBR is less clear. Therefore, this study aims to investigate the clinical effectiveness of PRF when used in ARR or GBR, as well as postoperative discomfort following these procedures.

Sources

A systematic search using the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) method was performed to include database searches from MEDLINE (OVID interface, 1946 onwards), EMBASE (OVID interface, 1974 onwards) and Global Health (OVID interface, 1973 onwards).

Data

Of the 74 studies initially identified, 7 studies were included for the systematic review, including 6 randomized controlled trials (RCTs) and 1 cohort study. The meta-analysis showed that the incorporation of PRF as part of ARR or GBR resulted in an increase in horizontal ridge width, a reduction in the rate of resorption increase, while postoperative discomfort was the same or slightly improved. The risk of bias quality was low for only 1 out of the 6 RCTs and the Newcastle Ottawa scale assessment showed that cohort study was of high quality.

Conclusion

PRF application in ARR or GBR is associated with increased horizonal alveolar ridge width and reduce rate of graft resorption. However, the findings related to both outcome measures were based on a limited number of studies.

Clinical significance

PRF application can be effectively used as part of ARR or GBR to increase the horizontal ridge width and reduce the rate of graft resorption

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来源期刊

Journal of dentistry 医学-牙科与口腔外科

CiteScore

7.30

自引率

11.40%

发文量

349

审稿时长

35 days

期刊介绍： The Journal of Dentistry has an open access mirror journal The Journal of Dentistry: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The Journal of Dentistry is the leading international dental journal within the field of Restorative Dentistry. Placing an emphasis on publishing novel and high-quality research papers, the Journal aims to influence the practice of dentistry at clinician, research, industry and policy-maker level on an international basis. Topics covered include the management of dental disease, periodontology, endodontology, operative dentistry, fixed and removable prosthodontics, dental biomaterials science, long-term clinical trials including epidemiology and oral health, technology transfer of new scientific instrumentation or procedures, as well as clinically relevant oral biology and translational research. The Journal of Dentistry will publish original scientific research papers including short communications. It is also interested in publishing review articles and leaders in themed areas which will be linked to new scientific research. Conference proceedings are also welcome and expressions of interest should be communicated to the Editor.