具有抗癌治疗潜力的1,2,3-三唑-(融合)六元含氮杂环杂环化合物的现状。

IF 4.3 3区 医学 Q2 CHEMISTRY, MEDICINAL
Zhi Xu, Rongqiang Li, Zhiwei Huang, Yafei Zhuang
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引用次数: 0

摘要

癌症的特点是异常细胞不受控制地生长和扩散,可能影响人体几乎所有组织,是全世界最具破坏性和致命的疾病之一。化疗是癌症治疗的主要方法之一,但多药耐药和严重的副作用是治疗成功的主要障碍,因此迫切需要开发新的化疗药物。1,2,3-三唑部分可以通过“点击化学”方便地构建,并且可以与癌细胞中的各种酶发生多种非共价相互作用。因此,1,2,3-三唑是最令人着迷的抗癌药效团之一。此外,1,2,3-三唑还可以作为复杂分子结构的强大连接工具,以提高铅分子的抗癌功效。值得注意的是,具有有趣结构变化的1,2,3-三唑类杂合体可以同时靶向癌细胞中的不同生物成分,这凸显了它们在治疗和根除癌症方面的潜力。本文综述了具有抗癌治疗潜力的1,2,3-三唑-喹唑啉类、1,2,3-三唑-喹唑啉类、1,2,3-三唑-喹啉类、1,2,3-三唑-喹诺酮类、1,2,3-三唑-吡啶类和1,2,3-三唑-嘧啶类六元含氮杂环杂环化合物的研究现状,并探讨了它们的作用机制、设计的关键方面以及构效关系(sar)。涵盖从2021年至今发表的文章,为开发创新和高效的癌症治疗干预措施铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The current landscape of 1,2,3-triazole-(fused) six-membered nitrogen-containing heteroaromatic ring hybrids with anticancer therapeutic potential

The current landscape of 1,2,3-triazole-(fused) six-membered nitrogen-containing heteroaromatic ring hybrids with anticancer therapeutic potential

Cancer, characterized by uncontrolled growth and spread of abnormal cells potentially influencing almost all tissues in the body, is one of the most devastating and lethal diseases throughout the world. Chemotherapy is one of the principal approaches for cancer treatment, but multidrug resistance and severe side effects represent the main barriers to the success of therapy, creating a vital need to develop novel chemotherapeutic agents. The 1,2,3-triazole moiety can be conveniently constructed by “click chemistry” and could exert diverse noncovalent interactions with various enzymes in cancer cells. Hence, 1,2,3-triazole is one of the most fascinating anticancer pharmacophores. Moreover, 1,2,3-triazole could also serve as a powerful ligation tool for the complex molecular architectures to increase the anticancer efficacy of lead molecules. Notably, 1,2,3-triazole-containing hybrids with intriguing structural variations could target different biological components in cancer cells simultaneously, highlighting their potential in the treatment and eradication of cancer. This review outlines the current landscape of 1,2,3-triazole-(fused) six-membered nitrogen-containing heteroaromatic ring hybrids, inclusive of 1,2,3-triazole-quinazolines, 1,2,3-triazole-quinazolinones, 1,2,3-triazole-quinolines, 1,2,3-triazole-quinolones, 1,2,3-triazole-pyridines, and 1,2,3-triazole-pyrimidines, with anticancer therapeutic potential, and explores their mechanisms of action, critical aspects of design as well as structure–activity relationships (SARs), covering articles published from 2021 to the present, to pave the way for the development of innovative and efficient therapeutic interventions for cancer therapy.

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来源期刊
Archiv der Pharmazie
Archiv der Pharmazie 医学-化学综合
CiteScore
7.90
自引率
5.90%
发文量
176
审稿时长
3.0 months
期刊介绍: Archiv der Pharmazie - Chemistry in Life Sciences is an international journal devoted to research and development in all fields of pharmaceutical and medicinal chemistry. Emphasis is put on papers combining synthetic organic chemistry, structural biology, molecular modelling, bioorganic chemistry, natural products chemistry, biochemistry or analytical methods with pharmaceutical or medicinal aspects such as biological activity. The focus of this journal is put on original research papers, but other scientifically valuable contributions (e.g. reviews, minireviews, highlights, symposia contributions, discussions, and essays) are also welcome.
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