8-甲基喹啉类化合物的C(sp3)-H键功能化。

IF 3.5 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - An Asian Journal Pub Date : 2024-12-30 DOI:10.1002/asia.202401266

Diksha Parmar, Rohit Kumar, Upendra Sharma

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引用次数: 0

摘要

喹啉类药物已成为各种药物的基本成分，在治疗各种疾病中起着关键作用。许多以喹啉为核心的药物已被公认具有抗疟、抗菌和抗癌活性，并已成功商业化，包括氯喹、环丙沙星、拓扑替康等。在过去的二十年里，我们见证了喹啉支架的C-H键功能化的巨大扩展，进一步拓宽了药物发现的化学空间。本文综述了8-甲基喹啉类化合物C(sp3)-H功能化在金属和无金属策略下形成C(sp3)-C/X键的研究进展。每个部分简要概述了8-甲基喹啉的C(sp3)-H功能化，重点介绍了金属和无金属的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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C(sp3)-H Bond Functionalization of 8-Methylquinolines.

Quinolines have emerged as essential components in various medicinal agents, playing a key role in treating various ailments. Numerous drugs with a quinoline core have been recognized for their antimalarial, antibacterial, and anticancer activities and have been successfully commercialized, including chloroquine, ciprofloxacin, topotecan, etc. Over the past two decades, we have witnessed a tremendous expansion in the C-H bond functionalization of quinoline scaffolds to widen this chemical space for drug discovery further. This review article summarizes the efforts toward C(sp3)-H functionalization of 8-methylquinolines for C(sp3)-C/X bond formation under metal and metal-free strategies. Each section briefly overviews the C(sp3)-H functionalization of 8-methylquinoline, highlighting the metal and metal-free approaches.

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来源期刊

Chemistry - An Asian Journal 化学-化学综合

CiteScore

7.00

自引率

2.40%

发文量

535

审稿时长

1.3 months

期刊介绍： Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews. A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal. Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).