{"title":"双侧可逆性角膜水肿是左乙拉西坦的新副作用- 1例报告。","authors":"Kimberly Caruana, Matthew Ellul, Andre Grixti","doi":"10.2147/IMCRJ.S497262","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>We present a case of levetiracetam-induced corneal edema. To the best of our knowledge, this is the first documented case of bilateral reversible corneal edema secondary to levetiracetam use.</p><p><strong>Patients and methods: </strong>A 59-year-old woman was referred to the ophthalmology department with a few weeks' history of bilateral blurring of vision. She is a known case of secondary progressive multiple sclerosis, and she was started on levetiracetam by her neurologist a few weeks prior to referral in view of new seizure activity. Examination revealed bilateral clinically evident corneal edema, which was documented on corneal topography.</p><p><strong>Results: </strong>Upon levetiracetam dose reduction, symptoms started to improve and eventually the medication was stopped altogether. The patient's vision and corneal edema normalized on follow-up.</p><p><strong>Conclusion: </strong>This novel side effect should be kept in mind when a patient who is on levetiracetam presents with corneal edema as this can avoid misdiagnosis and unnecessary interventions.</p>","PeriodicalId":14337,"journal":{"name":"International Medical Case Reports Journal","volume":"17 ","pages":"1069-1074"},"PeriodicalIF":0.7000,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11680862/pdf/","citationCount":"0","resultStr":"{\"title\":\"Bilateral Reversible Corneal Edema as a Novel Side-Effect of Levetiracetam - A Case Report.\",\"authors\":\"Kimberly Caruana, Matthew Ellul, Andre Grixti\",\"doi\":\"10.2147/IMCRJ.S497262\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>We present a case of levetiracetam-induced corneal edema. To the best of our knowledge, this is the first documented case of bilateral reversible corneal edema secondary to levetiracetam use.</p><p><strong>Patients and methods: </strong>A 59-year-old woman was referred to the ophthalmology department with a few weeks' history of bilateral blurring of vision. She is a known case of secondary progressive multiple sclerosis, and she was started on levetiracetam by her neurologist a few weeks prior to referral in view of new seizure activity. Examination revealed bilateral clinically evident corneal edema, which was documented on corneal topography.</p><p><strong>Results: </strong>Upon levetiracetam dose reduction, symptoms started to improve and eventually the medication was stopped altogether. The patient's vision and corneal edema normalized on follow-up.</p><p><strong>Conclusion: </strong>This novel side effect should be kept in mind when a patient who is on levetiracetam presents with corneal edema as this can avoid misdiagnosis and unnecessary interventions.</p>\",\"PeriodicalId\":14337,\"journal\":{\"name\":\"International Medical Case Reports Journal\",\"volume\":\"17 \",\"pages\":\"1069-1074\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2024-12-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11680862/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Medical Case Reports Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2147/IMCRJ.S497262\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Medical Case Reports Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/IMCRJ.S497262","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Bilateral Reversible Corneal Edema as a Novel Side-Effect of Levetiracetam - A Case Report.
Purpose: We present a case of levetiracetam-induced corneal edema. To the best of our knowledge, this is the first documented case of bilateral reversible corneal edema secondary to levetiracetam use.
Patients and methods: A 59-year-old woman was referred to the ophthalmology department with a few weeks' history of bilateral blurring of vision. She is a known case of secondary progressive multiple sclerosis, and she was started on levetiracetam by her neurologist a few weeks prior to referral in view of new seizure activity. Examination revealed bilateral clinically evident corneal edema, which was documented on corneal topography.
Results: Upon levetiracetam dose reduction, symptoms started to improve and eventually the medication was stopped altogether. The patient's vision and corneal edema normalized on follow-up.
Conclusion: This novel side effect should be kept in mind when a patient who is on levetiracetam presents with corneal edema as this can avoid misdiagnosis and unnecessary interventions.
期刊介绍:
International Medical Case Reports Journal is an international, peer-reviewed, open access, online journal publishing original case reports from all medical specialties. Submissions should not normally exceed 3,000 words or 4 published pages including figures, diagrams and references. As of 1st April 2019, the International Medical Case Reports Journal will no longer consider meta-analyses for publication.