早期妊娠可溶性sFlt-1预测早产子痫前期。

IF 2 Q2 OBSTETRICS & GYNECOLOGY

Journal of obstetrics and gynaecology Canada Pub Date : 2025-02-01 DOI:10.1016/j.jogc.2024.102753

Alexandre Fillion MD, MSc , Amélie Boutin PhD , Yves Giguère MD, PhD , Jean-Claude Forest MD, PhD , Louise Ghesquière MD, PhD , Emmanuel Bujold MD, MSc

{"title":"早期妊娠可溶性sFlt-1预测早产子痫前期。","authors":"Alexandre Fillion MD, MSc , Amélie Boutin PhD , Yves Giguère MD, PhD , Jean-Claude Forest MD, PhD , Louise Ghesquière MD, PhD , Emmanuel Bujold MD, MSc","doi":"10.1016/j.jogc.2024.102753","DOIUrl":null,"url":null,"abstract":"<div><div>While soluble fms-like tyrosine kinase 1 (sFlt-1) is used to predict preeclampsia (PE) and its severity in late pregnancy, we aimed to clarify its role in early pregnancy. Using prospective cohorts, we estimated the association between sFlt-1, adjusted for gestational age, and preterm PE. sFlt-1 was significantly decreased in the first trimester, mostly before the 13th week, and significantly increased in the third trimester in those who developed preterm PE and particularly early-onset PE. We hypothesize that sFlt-1 evolves from low to high values in early to late pregnancy among women with preterm and early-onset PE.</div></div>","PeriodicalId":16688,"journal":{"name":"Journal of obstetrics and gynaecology Canada","volume":"47 2","pages":"Article 102753"},"PeriodicalIF":2.0000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"First-Trimester Soluble fms-like Tyrosine Kinase 1 (sFlt-1) for the Prediction of Preterm Preeclampsia\",\"authors\":\"Alexandre Fillion MD, MSc , Amélie Boutin PhD , Yves Giguère MD, PhD , Jean-Claude Forest MD, PhD , Louise Ghesquière MD, PhD , Emmanuel Bujold MD, MSc\",\"doi\":\"10.1016/j.jogc.2024.102753\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>While soluble fms-like tyrosine kinase 1 (sFlt-1) is used to predict preeclampsia (PE) and its severity in late pregnancy, we aimed to clarify its role in early pregnancy. Using prospective cohorts, we estimated the association between sFlt-1, adjusted for gestational age, and preterm PE. sFlt-1 was significantly decreased in the first trimester, mostly before the 13th week, and significantly increased in the third trimester in those who developed preterm PE and particularly early-onset PE. We hypothesize that sFlt-1 evolves from low to high values in early to late pregnancy among women with preterm and early-onset PE.</div></div>\",\"PeriodicalId\":16688,\"journal\":{\"name\":\"Journal of obstetrics and gynaecology Canada\",\"volume\":\"47 2\",\"pages\":\"Article 102753\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of obstetrics and gynaecology Canada\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1701216324005760\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of obstetrics and gynaecology Canada","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1701216324005760","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

可溶性fms样酪氨酸激酶1 （sFlt-1）用于预测妊娠晚期子痫前期（PE）及其严重程度，我们旨在阐明其在妊娠早期的作用。使用前瞻性队列，我们估计了经胎龄调整后的sFlt-1与早产儿PE之间的关联。sFlt-1在妊娠前三个月显著降低，主要在第13周之前，而在发生早产PE特别是早发性PE的妊娠晚期显著升高。我们假设sFlt-1在早产和早发性PE妇女的妊娠早期和晚期由低值到高值演变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

First-Trimester Soluble fms-like Tyrosine Kinase 1 (sFlt-1) for the Prediction of Preterm Preeclampsia

While soluble fms-like tyrosine kinase 1 (sFlt-1) is used to predict preeclampsia (PE) and its severity in late pregnancy, we aimed to clarify its role in early pregnancy. Using prospective cohorts, we estimated the association between sFlt-1, adjusted for gestational age, and preterm PE. sFlt-1 was significantly decreased in the first trimester, mostly before the 13th week, and significantly increased in the third trimester in those who developed preterm PE and particularly early-onset PE. We hypothesize that sFlt-1 evolves from low to high values in early to late pregnancy among women with preterm and early-onset PE.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of obstetrics and gynaecology Canada OBSTETRICS & GYNECOLOGY-

CiteScore

3.30

自引率

5.60%

发文量

302

审稿时长

32 days

期刊介绍： Journal of Obstetrics and Gynaecology Canada (JOGC) is Canada"s peer-reviewed journal of obstetrics, gynaecology, and women"s health. Each monthly issue contains original research articles, reviews, case reports, commentaries, and editorials on all aspects of reproductive health. JOGC is the original publication source of evidence-based clinical guidelines, committee opinions, and policy statements that derive from standing or ad hoc committees of the Society of Obstetricians and Gynaecologists of Canada. JOGC is included in the National Library of Medicine"s MEDLINE database, and abstracts from JOGC are accessible on PubMed.