使用多细胞模拟鉴定上皮单层屈曲的竞争机制。

IF 1.9 4区数学 Q2 BIOLOGY

Mathematical Biosciences Pub Date : 2025-02-01 DOI:10.1016/j.mbs.2024.109367

Phillip J. Brown , J. Edward F. Green , Benjamin J. Binder , James M. Osborne

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引用次数: 0

摘要

采用刚体多细胞框架（RBMCF）模型来研究上皮单层屈曲的机制。具体地说，是附着在基底膜和周围基质组织上的上皮细胞单层的变形。上皮单分子层、支持基底膜和基质组织使用两个单独的顶点动力学模型（一个用于上皮单分子层，另一个用于基底膜和基质组织组合）进行建模，并使用RBMCF考虑两者之间的相互作用，以确保生物学上真实的相互作用。模型模拟用于研究细胞间质附着和膜刚度对屈曲行为的影响。我们证明存在两种相互竞争的屈曲模式，即基质变形和基质分离。

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Competing mechanisms for the buckling of an epithelial monolayer identified using multicellular simulation

A model using the rigid body multi-cellular framework (RBMCF) is implemented to investigate the mechanisms of buckling of an epithelial monolayer. Specifically, the deformation of a monolayer of epithelial cells which are attached to a basement membrane and the surrounding stromal tissue. The epithelial monolayer, supporting basement membrane and stromal tissue are modelled using two separate vertex dynamics models (one for the epithelial monolayer layer and one for the basement membrane and stromal tissue combined) and interactions between the two are considered using the RBMCF to ensure biologically realistic interactions. Model simulations are used to investigate the effects of cell–stromal attachment and membrane rigidity on buckling behaviour. We demonstrate that there are two competing modes of buckling, stromal deformation and stromal separation.

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来源期刊

Mathematical Biosciences 生物-生物学

CiteScore

7.50

自引率

2.30%

发文量

审稿时长

18 days

期刊介绍： Mathematical Biosciences publishes work providing new concepts or new understanding of biological systems using mathematical models, or methodological articles likely to find application to multiple biological systems. Papers are expected to present a major research finding of broad significance for the biological sciences, or mathematical biology. Mathematical Biosciences welcomes original research articles, letters, reviews and perspectives.